ACMUCABTAGENE AUTOLEUCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Wed Apr 02 13:57:19 GMT 2025` Edited by `admin` on `Wed Apr 02 13:57:19 GMT 2025`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	blood
Fraction Material Type	cells
Fraction Name	t cells
Record UNII	33KHD8ZZ8Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ACMUCABTAGENE AUTOLEUCEL

Official Name

English

AUTOLOGOUS T CELLS OBTAINED FROM PERIPHERAL BLOOD MONONUCLEAR CELLS BY LEUKAPHERESIS, TRANSDUCED WITH A SELFINACTIVATING, NON-REPLICATING LENTIVIRAL VECTOR, ENCODING A CHIMERIC ANTIGEN RECEPTOR (CAR) TARGETING B-LYMPHOCYTE ANTIGEN CD19 (ALSO KNOWN AS B-L

Preferred Name

English

acmucabtagene autoleucel [INN]

Common Name

English

Code System Code Type Description

INN

11832

Created by admin on Wed Apr 02 13:57:19 GMT 2025 , Edited by admin on Wed Apr 02 13:57:19 GMT 2025

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FDA UNII

33KHD8ZZ8Y

Created by admin on Wed Apr 02 13:57:19 GMT 2025 , Edited by admin on Wed Apr 02 13:57:19 GMT 2025

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NCI_THESAURUS

C203090

Created by admin on Wed Apr 02 13:57:19 GMT 2025 , Edited by admin on Wed Apr 02 13:57:19 GMT 2025

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SMS_ID

300000056444

Created by admin on Wed Apr 02 13:57:19 GMT 2025 , Edited by admin on Wed Apr 02 13:57:19 GMT 2025

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Related Record Type Details


					TYR224OK86

CD19 POSITIVE CELLS

TARGET->CYTOTOXIC T-CELL

Amount:

Related Record Type Details


					33KHD8ZZ8Y

ACMUCABTAGENE AUTOLEUCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Fragment Name	Fragment ID
CULTURE		HUMAN INTERLEUKIN-2	FNO32LO217
LENTIVIRAL TRANSFECTION	TRANSFECTION	ACMUCABTAGENE AUTOLEUCEL VECTOR	UG6BGQ2UWP
CULTURE	ACTIVATOR	UNSPECIFIED SUBSTANCE	a64e131d
CULTURE		INTERLEUKIN-7 HUMAN RECOMBINANT	418XB47Y71

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					ACMUCABTAGENE AUTOLEUCEL EXPRESSED PROTEIN	T47V958ZJ3
INSERTED GENE EXPRESSION VECTOR					ACMUCABTAGENE AUTOLEUCEL TRANSGENE INSERT	4EDN5ZS6P9

Name	Property Type	Referenced Substance
ANTIGEN EXPRESSED	BIOLOGICAL	`2946IE3VYD` CD8

ANTIGEN EXPRESSED	BIOLOGICAL	`8OYI5QX0HL` T-CELL SURFACE GLYCOPROTEIN CD4