CIAMEXON

Details

Stereochemistry	RACEMIC
Molecular Formula	C11H13N3O
Molecular Weight	203.2404
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=NC(C)=CC=C1CN2CC2C#N

InChI

InChIKey=KOYMTVWMCXDJNV-UHFFFAOYSA-N

InChI=1S/C11H13N3O/c1-8-3-4-9(11(13-8)15-2)6-14-7-10(14)5-12/h3-4,10H,6-7H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C11H13N3O
Molecular Weight	203.2404
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2189417 | https://www.ncbi.nlm.nih.gov/pubmed/3303793 | https://www.ncbi.nlm.nih.gov/pubmed/2533393 | https://www.ncbi.nlm.nih.gov/pubmed/3325216

Ciamexon is an aziridine derivative with potent immuno-modulating activity developed by German pharmaceutical company Boehringer Mannheim G.m.b.H. for autoimmune diseases treatment. Ciamexon shows promising effects in experimental models of rheumatoid arthritis, diabetes, and obesity without toxic side effects. In animal studies, Ciamexon inhibits the proliferation of autoreactive lymphocytes dose-dependently, without affecting the reaction against foreign antigens. Clinical efficacy evaluation of the Ciamexon in patients with rheumatoid arthritis shows significant, dose-dependent improvement in both the clinical and the biochemical disease activity indexes. The major adverse effects of Ciamexon were hepatotoxicity, diarrhea, and rash.

Originator

Approval Year

PubMed

Title	Date	PubMed
A randomized controlled trial of ciamexon versus placebo in the immunomodulatory treatment of rheumatoid arthritis.	1990 May	2189417

Patents

Sample Use Guides

In Vivo Use Guide

400 mg/day of ciamexon for 6 mounths

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:32:54 GMT 2023` Edited by `admin` on `Fri Dec 15 16:32:54 GMT 2023`
Record UNII	325PG708LF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

CIAMEXON

Official Name

English

CIAMEXON [MART.]

Common Name

English

ciamexon [INN]

Common Name

English

BM-41332

Code

English

(±)-1-((2-METHOXY-6-METHYL-3-PYRIDYL)METHYL)-2-AZIRIDINECARBONITRILE

Systematic Name

English

BM 41.332

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C308