U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C40H80NO8P
Molecular Weight 734.0389
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of COLFOSCERIL PALMITATE

SMILES

CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC

InChI

InChIKey=KILNVBDSWZSGLL-KXQOOQHDSA-N
InChI=1S/C40H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h38H,6-37H2,1-5H3/t38-/m1/s1

HIDE SMILES / InChI
Molecular Formula C40H80NO8P
Molecular Weight 734.0389
Charge 0
Count
Stereochemistry EPIMERIC
Additional Stereochemistry No
Defined Stereocenters 1 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Colfosceril palmitate (dipalmitoylphosphatidylcholine) is a synthetic pulmonary surfactant, which is used in infants with respiratory distress syndrome it was approved in 1990, but nowadays it is under the state of canceled post-marketing. Colfosceril palmitate is reducing the tension and stabilizing the alveoli from collapsing.

Originator

Approval Year

1990
111
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Approved
8583
EXOSURF NEONATAL

Approved Use

Exosurf® is only for the treatment or prevention of respiratory distress syndrome in newborn infants

Launch Date

2000
Sourcing

Sourcing

Vendor/AggregatorIDURL
3B Scientific (Wuhan) Corp
3B2-5565
http://www.3bsc.com/index/pro_info.php?id=85367
AA Blocks
AA003DBZ
http://www.aablocks.com/goods/Goods/detail?id=AA003DBZ
Aaron Chemicals
AR003E3R
http://www.aaronchem.com/63-89-8
abcr GmbH
AB331720
http://www.abcr.com/shop/en/AB331720
Acros Organics
AC240570025
https://www.fishersci.com/shop/products/l-alpha-dipalmitoyl-phosphatidylcholine-98-acros-organics-2/AC240570025
AEchem Scientific Corp., USA
AE052774
http://www.aechemsc.com/info_products/AE052774.php
AHH Chemical co.,ltd
MT-53101
http://www.ahhchemical.com/product/MT-53101.html
AK Scientific, Inc. (AKSCI)
K017
http://www.aksci.com/item_detail.php?cat=K017
Ambeed
A542590
https://www.ambeed.com/products/63-89-8.html
Angene
AGN-PC-0TADZG
http://www.angenechemical.com/productshow/AGN-PC-0TADZG.html
Aurora Fine Chemicals LLC
A17.876.272
http://online.aurorafinechemicals.com/info?ID=A17.876.272
Aurora Fine Chemicals LLC
K14.820.059
http://online.aurorafinechemicals.com/info?ID=K14.820.059
BLD Pharm
BD53403
http://www.bldpharm.com/products/63-89-8.html
Chem Scene
CS-0031214
http://www.chemscene.com/63-89-8.html
Chemenu
CM129196
http://www.chemenu.com/products/CM129196
Chemspace
CSSB00000053731
https://chem-space.com/CSSB00000053731
CSNpharm
CSN17079
https://www.csnpharm.com/products/colfosceril-palmitate.html
DC Chemicals
DC32182
http://www.dcchemicals.com//product_show-Colfosceril_Palmitate.html
eNovation Chemicals
D955234
https://www.enovationchem.com/ProductDetails.asp?ProductID=D955234
Glentham Life Sciences
GL3400
http://www.glentham.com/products/product/GL3400/
MedChem Express
HY-109506
https://www.medchemexpress.com/DPPC.html
Sigma-Aldrich
850355P_AVANTI
https://www.sigmaaldrich.com/catalog/product/avanti/850355p?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
P0763_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/p0763?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich
P4329_SIGMA
https://www.sigmaaldrich.com/catalog/product/sigma/p4329?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule
S532689
http://www.smolecule.com/products/s532689
TCI (Tokyo Chemical Industry)
D3925
http://www.tcichemicals.com/eshop/en/us/commodity/D3925/index.html
THE BioTek
bt-272861
https://www.thebiotek.com/product/inhibitors/bt-272861
VladaChem
VL280798-25MG
https://www.vladachem.com/product.php?products=63-89-8
PubMed

PubMed

TitleDatePubMed
A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.
2005-04
Colfosceril palmitate. A pharmacoeconomic evaluation of a synthetic surfactant preparation (Exosurf Neonatal) in infants with respiratory distress syndrome.
1994-12
Unilateral pulmonary interstitial emphysema and treatment with colfosceril palmitate.
1993-06-19
Colfosceril palmitate. A review of the therapeutic efficacy and clinical tolerability of a synthetic surfactant preparation (Exosurf Neonatal) in neonatal respiratory distress syndrome.
1991-11
Patents

Patents

EP1976535A2
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 17:57:13 GMT 2025
Edited
by admin
on Mon Mar 31 17:57:13 GMT 2025
Record UNII
319X2NFW0A
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
COLFOSCERIL PALMITATE
DASH   INN   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
INN   USAN  
Official Name English
DIPALMITOYL GLYCEROPHOSPHOCHOLINE
INCI  
INCI  
Preferred Name English
DPPC, L-
Common Name English
3,5,9-TRIOXA-4-PHOSPHAPENTACOSAN-1-AMINIUM, 4-HYDROXY-N,N,N-TRIMETHYL-10-OXO-7-((1-OXOHEXADECYL)OXY)-, HYDROXIDE, INNER SALT, 4-OXIDE, (R)-
Common Name English
colfosceril palmitate [INN]
Common Name English
1.2 DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE
Common Name English
COLFOSCERIL PALMITATE [USAN]
Common Name English
DIPALMITOYL LECITHIN, L-
Common Name English
COLFOSCERIL [VANDF]
Common Name English
1,2-DIHEXADECANOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Common Name English
129Y83
Code English
OP0201 COMPONENT COLFOSCERIL PALMITATE
Common Name English
CHOLINE HYDROXIDE, DIHYDROGEN PHOSPHATE, INNER SALT, ESTER WITH L-1,2-DIPALMITIN
Common Name English
COLFOSCERIL PALMITATE [ORANGE BOOK]
Common Name English
Colfosceril palmitate [WHO-DD]
Common Name English
DPPC, R-
Common Name English
DIPALMITOYLPHOSPHATIDYLCHOLINE
Common Name English
COLFOSCERIL PALMITATE [VANDF]
Common Name English
EXOSURF NEONATAL COMPONENT COLFOSCERIL PALMITATE
Common Name English
OP-0201 COMPONENT COLFOSCERIL PALMITATE
Common Name English
1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Common Name English
1.2 DIPALMITOYL-SN-GLYCERO-3-PHOSPHATIDYLCHOLINE (DPPC)
Common Name English
LUCINACTANT COMPONENT DPPC
Common Name English
COLFOSCERIL PALMITATE [MI]
Common Name English
129-Y-83
Code English
SURFAXIN COMPONENT DPPC
Brand Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 68492
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
WHO-VATC QR07AA01
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
LOINC 2215-2
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
FDA ORPHAN DRUG 14886
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
NCI_THESAURUS C78273
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
FDA ORPHAN DRUG 29688
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
WHO-ATC R07AA01
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
Code System Code Type Description
RXCUI
69782
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
DRUG CENTRAL
730
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
NCI_THESAURUS
C47462
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
EVMPD
SUB22681
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
ECHA (EC/EINECS)
200-567-6
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
CAS
63-89-8
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
SMS_ID
100000084265
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
FDA UNII
319X2NFW0A
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
MERCK INDEX
m3731
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY Merck Index
DRUG BANK
DB09114
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
MESH
C081581
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
ChEMBL
CHEMBL1200737
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
PUBCHEM
452110
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
INN
6728
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
RXCUI
107784
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
ALTERNATIVE
DAILYMED
319X2NFW0A
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
CHEBI
72999
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
EVMPD
SUB06799MIG
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
USAN
AA-82
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
CHEBI
40265
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
EPA CompTox
DTXSID5046720
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
WIKIPEDIA
COLFOSCERIL PALMITATE
Created by admin on Mon Mar 31 17:57:13 GMT 2025 , Edited by admin on Mon Mar 31 17:57:13 GMT 2025
PRIMARY
Related Record Type Details
Structure of COLFOSCERIL PALMITATE
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966