BIXALOMER

Description
Sources: https://www.astellas.com/en/corporate/news/pdf/120625_Eg.pdf | https://www.ncbi.nlm.nih.gov/pubmed/28194884

Bixalomer (development code: ASP15 and brand name Kiklin) is a metal-free, nonabsorbable is approved in Japan to treat hyperphosphatemia in dialysis patients. Hyperphosphatemia occurs in patients whose renal function is decreased, since phosphorus is not sufficiently excreted into urine via the kidneys and consequently accumulates in the body. Bixalomer is amine-functional polymers which decrease the serum phosphorus concentration by binding to phosphate in the gastrointestinal tract, thus inhibiting absorption of phosphate into the human body.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
phosphate 1 Target ID: phosphate Sources: https://www.ncbi.nlm.nih.gov/pubmed/26452517	Binding Agent 1064

Conditions

Condition	Modality	Targets	Highest Phase	Product
Hyperphosphatemia 30 Sources: https://www.astellas.com/en/corporate/news/pdf/120625_Eg.pdf	Primary		Approved 8429	Kiklin Approved Use for the indication of treatment of hyperphosphatemia in patients with chronic kidney disease Launch Date 1.3405824E12

PubMed

Title	Date	PubMed
Bixalomer, a novel phosphate binder with a small swelling index, improves hyperphosphatemia in chronic kidney disease rat.	2015 Nov 5	26452517
Bixalomer in Hyperphosphatemic Patients With Chronic Kidney Disease Not on Dialysis: Phase 3 Randomized Trial.	2016 Dec	27896908
Long-Term Safety and Efficacy of Bixalomer in Hyperphosphatemic Patients With Chronic Kidney Disease Not on Dialysis.	2017 Apr	28194884
Research on kidney and mineral metabolism in Japan: past, present, and future.	2017 Mar	28005175

Sample Use Guides

In Vivo Use Guide

Kiklin (bixalomer) is usually taken orally 2 capsules, 3 times per day or as directed by a doctor. The capsules should be taken just before meals along with some water.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Polymer Created by `admin` on `Sat Dec 16 15:57:55 UTC 2023` Edited by `admin` on `Sat Dec 16 15:57:55 UTC 2023`
Record UNII	3160WY51LV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BIXALOMER

Official Name

English

AMG-223

Code

English

Bixalomer [WHO-DD]

Common Name

English

ASP1585

Code

English

BIXALOMER [USAN]

Common Name

English

KIKLIN

Brand Name

English

ILY101

Code

English

ILY-101

Code

English

1,4-BUTANEDIAMINE, N,N,N',N'-TETRAKIS(3-AMINOPROPYL)-, POLYMER WITH 2-(CHLOROMETHYL)OXIRANE

Common Name

English

BIXALOMER [JAN]

Common Name

English

ASP-1585

Code

English

N,N,N',N'-TETRAKIS(3-AMINOPROPYL)BUTANE-1,4-DIAMINE POLYMER WITH 2-(CHLOROMETHYL)OXIRANE

Common Name

English

BIXALOMER [MI]

Common Name

English

bixalomer [INN]

Common Name

English

Code System Code Type Description

INN

9096