Dextranomer is a hydrophilic dextran polymer used as a biocompatible bulking agent, administered by submucosal injection. Dextranomer / hyaluronic acid treatment was associated with symptomatic improvement in adult fecal incontinence patients participating in a randomized, double-blind, study and non-comparative multinational study. Although there is limited discussion of the mechanism of action of dextranomer / hyaluronic acid in the literature, it is assumed that the dextranomer can expand the submucosal layer of the proximal anal canal, thereby increasing intestinal control. Dextranomer has been used as a 'cleansing agent' for various types of exudative wounds or ulcers, including stasis and pressure ulcers. Dextranomer appears to exert its effect due to capillary action, which absorbs wound exudate, as well as wound debris and microorganisms into the dextranomer beads or between the balls, thus removing such products from the surface of the wound. Dextranomer is an adjunct to the treatment of wounds or ulcers and does not have a direct effect on tissue repair in such ulcers, but, as in the case of other “cleansing” agents or methods, one can expect removal of residues (and possibly microorganisms) from the wound will promote natural healing.
Approval Year
Substance Class |
Polymer
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Sat Dec 16 01:52:37 GMT 2023
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Sat Dec 16 01:52:37 GMT 2023
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30KXI0TVD3
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Validated (UNII)
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WHO-ATC |
D03AX02
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WHO-VATC |
QD03AX02
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100000087785
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C013471
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30KXI0TVD3
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m4222
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3822
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22708
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DB13560
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56087-11-7
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C166616
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Dextranomer
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CHEMBL2108201
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Related Record | Type | Details | ||
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ACTIVE MOIETY |
Agent Modifications
Modification Process | Modification Role | Modification Type | Amount | Fragment Name | Fragment ID |
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CROSSLINKING | CROSSLINKER | CROSSLINKER |
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EPICHLOROHYDRIN | 08OOR508C0 |