AMISOMETRADINE

US Previously Marketed

First approved in 1956

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H13N3O2
Molecular Weight	195.2184
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C(=O)C=C(N)N(CC(C)=C)C1=O

InChI

InChIKey=FXNYSZHYMGWWEZ-UHFFFAOYSA-N

InChI=1S/C9H13N3O2/c1-6(2)5-12-7(10)4-8(13)11(3)9(12)14/h4H,1,5,10H2,2-3H3

HIDE SMILES / InChI

Molecular Formula	C9H13N3O2
Molecular Weight	195.2184
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13489295 | https://www.ncbi.nlm.nih.gov/pubmed/13651512

AMISOMETRADINE, a pyrimidinedione-based diuretic, is an isomer of aminometradine with less toxicity and a reasonable diuretic potency.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Heart failure 106 Sources: https://www.ncbi.nlm.nih.gov/pubmed/13489295	Palliative		Not Provided 511	Rolicton Approved Use Unknown

Doses

Dose	Population	Adverse events
800 mg 3 times / day multiple, oral Studied dose Dose: 800 mg, 3 times / day Route: oral Route: multiple Dose: 800 mg, 3 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/13651512	unhealthy Health Status: unhealthy Sources: https://pubmed.ncbi.nlm.nih.gov/13651512	Sources: https://pubmed.ncbi.nlm.nih.gov/13651512

Sourcing

Vendor/Aggregator	ID	URL
AA Blocks	AA00DNJ2	http://www.aablocks.com/goods/Goods/detail?id=AA00DNJ2
AHH Chemical co.,ltd	MR-1013833	http://www.ahhchemical.com/product/MR-1013833.html
Ambinter	Amb24336014	http://www.ambinter.com/reference/24336014
Aurora Fine Chemicals LLC	A24.076.999	http://online.aurorafinechemicals.com/info?ID=A24.076.999
BLD Pharm	BD114036	http://www.bldpharm.com/products/550-28-7.html
ChemMol	99104168	http://www.chemmol.com/chemmol/99104168.html
Chemspace	CSSB00000076854	https://chem-space.com/CSSB00000076854
Clearsynth	CS-T-66362	https://www.clearsynth.com/en/CST66362.html
DC Chemicals	DC36050	http://www.dcchemicals.com//product_show-Amisometradine.html
Enamine	Z2286637826	https://www.enaminestore.com/catalog/Z2286637826
Smolecule	S518665	http://www.smolecule.com/products/s518665
Smolecule	S661135	https://www.smolecule.com/products/s661135
THE BioTek	bt-259591	https://www.thebiotek.com/product/inhibitors/bt-259591

PubMed

Title	Date	PubMed
Amisometradine (rolicton) in the treatment of congestive heart failure.	1959-04	13651512
Amisometradine, a new oral diuretic.	1958-01-04	13489295
Aminoisometradine (rolicton) as an oral diuretic in congestive heart failure.	1957-11-15	13483909

Patents

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:57:03 GMT 2025` Edited by `admin` on `Wed Apr 02 09:57:03 GMT 2025`
Record UNII	30973N61ZF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMISOMETRADINE

Official Name

English

NSC-70479

Preferred Name

English

2,4(1H,3H)-PYRIMIDINEDIONE, 6-AMINO-3-METHYL-1-(2-METHYL-2-PROPENYL)-

Systematic Name

English

amisometradine [INN]

Common Name

English

AMISOMETRADINE [MI]

Common Name

English

6-AMINO-3-METHYL-1-(2-METHYLALLYL)-2,4(1H,3H)-PYRIMIDINEDIONE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C448