SEQUIFENADINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H27NO.ClH
Molecular Weight	357.917
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of SEQUIFENADINE HYDROCHLORIDE

Structure Search

SMILES

Cl.CC1=C(C=CC=C1)C(O)(C2CN3CCC2CC3)C4=C(C)C=CC=C4

InChI

InChIKey=WCYWFJOJKZCSAJ-UHFFFAOYSA-N

InChI=1S/C22H27NO.ClH/c1-16-7-3-5-9-19(16)22(24,20-10-6-4-8-17(20)2)21-15-23-13-11-18(21)12-14-23;/h3-10,18,21,24H,11-15H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C22H27NO
Molecular Weight	321.4559
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.degruyter.com/downloadpdf/j/prolas.2010.64.issue-5-6/v10046-011-0001-9/v10046-011-0001-9.pdf | https://36i6.info/sehifenadin-sequifenadine/ | https://www.ncbi.nlm.nih.gov/pubmed/2575827

Sequifenadine is H1- and 5HT-serotonine receptor antagonist. It has an anti-histamine effect, not only blocking histamine receptors, but also reducing the content of histamine in tissues by accelerating its destruction by diamine oxidase. Sequifenadine did not demonstrate any significant sedative effect. It has a pronounced and prolonged antipruritic and antiexudative effect. It is indicated for the treatment of allergic rhinitis and conjunctivitis, pollinosis, urticaria, angioedema, allergic pruritic dermatosis, including atopic dermatitis. Adverse effects are: dry mouth, pain in the epigastric region, dyspepsia, increased appetite, headache, sleepiness.

Approval Year

Sample Use Guides

In Vivo Use Guide

50-100 mg 2-3 times per day. The course of treatment is 5-15 days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 11:46:30 GMT 2023` Edited by `admin` on `Sat Dec 16 11:46:30 GMT 2023`
Record UNII	305T85J01Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SEQUIFENADINE HYDROCHLORIDE

Common Name

English

BICARFEN

Brand Name

English

1-AZABICYCLO(2.2.2)OCTANE-3-METHANOL, .ALPHA.,.ALPHA.-BIS(2-METHYLPHENYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

BICARPHEN

Brand Name

English

Sequifenadine hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

SMS_ID

100000128096