SSR-180711 HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H17BrN2O2.ClH
Molecular Weight	361.662
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.BrC1=CC=C(OC(=O)N2CCN3CCC2CC3)C=C1

InChI

InChIKey=YNBXNVUZXFMNSJ-UHFFFAOYSA-N

InChI=1S/C14H17BrN2O2.ClH/c15-11-1-3-13(4-2-11)19-14(18)17-10-9-16-7-5-12(17)6-8-16;/h1-4,12H,5-10H2;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C14H17BrN2O2
Molecular Weight	325.201
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Neuronal acetylcholine receptor subunit alpha-7 14 Target ID: P36544 Gene ID: 1139\|\|\|89832 Gene Symbol: CHRNA7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/17019409	Partial Agonist 290		14.0 nM [Ki]
Neuronal acetylcholine receptor subunit alpha-7 14 Target ID: P36544 Gene ID: 1139\|\|\|89832 Gene Symbol: CHRNA7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/16936709 \| https://www.ncbi.nlm.nih.gov/pubmed/17019409	Partial Agonist 290		14.0 nM [Ki]

PubMed

Title	Date	PubMed
Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice.	2009 Jan 5	18848931
α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.	2010 May 27	21249164

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 18:34:36 GMT 2023` Edited by `admin` on `Sat Dec 16 18:34:36 GMT 2023`
Record UNII	2ZY6YR5A3C
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SSR-180711 HYDROCHLORIDE

Code

English

SSR-180711A

Code

English

1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLIC ACID 4-BROMOPHENYL ESTER HYDROCHLORIDE

Systematic Name

English

1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLIC ACID, 4-BROMOPHENYL ESTER, MONOHYDROCHLORIDE

Systematic Name

English

4-BROMOPHENYL 1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLATE MONOHYDROCHLORIDE

Systematic Name

English

1,4-DIAZABICYCLO(3.2.2)NONANE-4-CARBOXYLIC ACID, 4-BROMOPHENYL ESTER, HYDROCHLORIDE (1:1)

Common Name

English

Code System Code Type Description

FDA UNII

2ZY6YR5A3C

Created by admin on Sat Dec 16 18:34:36 GMT 2023 , Edited by admin on Sat Dec 16 18:34:36 GMT 2023

PRIMARY

CAS

446031-79-4

Created by admin on Sat Dec 16 18:34:36 GMT 2023 , Edited by admin on Sat Dec 16 18:34:36 GMT 2023

PRIMARY

PUBCHEM

9928899

Created by admin on Sat Dec 16 18:34:36 GMT 2023 , Edited by admin on Sat Dec 16 18:34:36 GMT 2023

PRIMARY

PUBCHEM

Related Record Type Details


					QF4P1U1666

SSR-180711

PARENT -> SALT/SOLVATE

Amount: