Vobramitamab Duocarmazine

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 22:03:52 GMT 2025` Edited by `admin` on `Tue Apr 01 22:03:52 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	2ZK3D69DQJ
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MGC-018

Preferred Name

English

Vobramitamab Duocarmazine

Official Name

English

AEX4089DC1

Common Name

English

Vobramitamab duocarmazine [WHO-DD]

Common Name

English

MGC018

Code

English

vobramitamab duocarmazine [INN]

Common Name

English

Immunoglobulin G1 [de-447-lysine], anti-(human B7 homolog 3 protein)(human-Mus musculus monoclonal PRCA157 ?1-chain), disulfide with human-Mus musculus monoclonal PRCA157 ?-chain, dimer, thioether with N-[[2-[2-(3-mercapto-2,5-dioxo-1-pyrrolidinyl)ethoxy

Common Name

English

ANTI-B7H3 ANTIBODY-DRUG CONJUGATE MGC018

Common Name

English

VOBRAMITAMAB DUOCARMAZINE [USAN]

Common Name

English

Code System Code Type Description

USAN

KL-246

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

CAS

2490556-51-7

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

INN

12056

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

FDA UNII

2ZK3D69DQJ

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

NCI_THESAURUS

C159495

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

NCIT

SMS_ID

300000041549

Created by admin on Tue Apr 01 22:03:52 GMT 2025 , Edited by admin on Tue Apr 01 22:03:52 GMT 2025

PRIMARY

From	To
1_22	1_96
1_144	1_200
1_220	3_215
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425
2_22	2_96
2_144	2_200
2_220	4_215
2_261	2_321
2_367	2_425
3_23	3_88
3_135	3_195
4_23	4_88
4_135	4_195

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					961Y201EWR

TARGET->CONJUGATED TOXIN

Amount:

Related Record Type Details


					LU3A693LFA

DUBA

METABOLITE ACTIVE -> PARENT

Amount:

Related Record Type Details


					2ZK3D69DQJ

Vobramitamab Duocarmazine

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		RESIDUE_SPECIFIC		Amount:	SECO-DUBA-LINKER-CYS	UWX7VBI64S
AMINO ACID REMOVAL	[1_447] [2_447]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL