BCH-2763

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C64H93N11O16
Molecular Weight	1272.4873
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(O)=O)NC(=O)CCCCN)C(=O)N3CCC[C@H]3C(=O)N([C@@H](CC(C)C)C(O)=O)C(=O)CCCCNC(=O)[C@@H]4CCCN4C(=O)[C@H](N)CC5=CC=CC=C5

InChI

InChIKey=VKIPOMGKUAJAEY-GEPLSBMPSA-N

InChI=1S/C64H93N11O16/c1-5-40(4)55(71-59(85)48-24-17-33-73(48)61(87)44(28-29-53(78)79)69-56(82)45(37-42-21-10-7-11-22-42)70-57(83)46(38-54(80)81)68-51(76)26-12-14-30-65)63(89)74-34-18-25-49(74)62(88)75(50(64(90)91)35-39(2)3)52(77)27-13-15-31-67-58(84)47-23-16-32-72(47)60(86)43(66)36-41-19-8-6-9-20-41/h6-11,19-22,39-40,43-50,55H,5,12-18,23-38,65-66H2,1-4H3,(H,67,84)(H,68,76)(H,69,82)(H,70,83)(H,71,85)(H,78,79)(H,80,81)(H,90,91)/t40-,43+,44-,45-,46-,47-,48-,49-,50-,55-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C64H93N11O16
Molecular Weight	1272.4873
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Drug-induced lysosomal changes and nephrotoxicity in rats.	1978 Nov	735819
Inhibition of the growth of human coronavirus 229E by leupeptin.	1985 Feb	3968542
Purification and biochemical characterization of recombinant simian immunodeficiency virus protease and comparison to human immunodeficiency virus type 1 protease.	1991 Aug 27	1883829
Peptide aldehydes as inhibitors of HIV protease.	1993 Mar 22	8458418
Antiviral effect of oryzacystatin, a proteinase inhibitor in rice, against herpes simplex virus type 1 in vitro and in vivo.	1995 Apr	7785982
Efficacy of serine protease inhibitors against Cryptosporidium parvum infection in a bovine fallopian tube epithelial cell culture system.	1996 Aug	8691375
Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation.	1996 Dec	9124840
Characterization of cytochrome P4502E1 turnover in transfected HepG2 cells expressing human CYP2E1.	1997 May 1	9143349
Inhibition of proteolysis by a cyclooxygenase inhibitor, indomethacin.	2000 Nov	11071371
Proteasomal degradation of caspase-6 in 17beta-estradiol-treated neurons.	2004 May	15086513
Activation and enzymatic characterization of recombinant human kallikrein 8.	2006 Jun	16800733
Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis.	2006 May	16242776
Endothelial gap junctions are down-regulated by arsenic trioxide.	2007 Aug 13	17559834
Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis.	2007 Jul 27	17488708
Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis.	2007 Mar	17110522
2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) induces degradation of adherens junction proteins and inhibits beta-catenin-dependent transcription in liver epithelial cells.	2009 Jun 16	19464575
Molecular modeling: a search for a calpain inhibitor as a new treatment for cataractogenesis.	2011 Nov 10	21955158
Urban particulate matter activates Akt in human lung cells.	2012 Jan	21818627

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:31:48 GMT 2023` Edited by `admin` on `Sat Dec 16 10:31:48 GMT 2023`
Record UNII	2Y77S7IT1P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BCH-2763

Common Name

English

L-LEUCINE, D-PHENYLALANYL-L-PROLYL-5-AMINOPENTANOYL-5-AMINOPENTANOYL-L-.ALPHA.-ASPARTYL-L-PHENYLALANYL-L-.ALPHA.-GLUTAMYL-L-PROLYL-L-ISOLEUCYL-L-PROLYL-

Systematic Name

English

Code System Code Type Description

CAS

204641-27-0

Created by admin on Sat Dec 16 10:31:48 GMT 2023 , Edited by admin on Sat Dec 16 10:31:48 GMT 2023

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PUBCHEM

72941757

Created by admin on Sat Dec 16 10:31:48 GMT 2023 , Edited by admin on Sat Dec 16 10:31:48 GMT 2023

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FDA UNII

2Y77S7IT1P

Created by admin on Sat Dec 16 10:31:48 GMT 2023 , Edited by admin on Sat Dec 16 10:31:48 GMT 2023

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Related Record Type Details


					2Y77S7IT1P

BCH-2763

ACTIVE MOIETY