BO-653

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H44O2
Molecular Weight	388.6264
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCC1(CCCCC)CC2=C(C(O)=C(C=C2O1)C(C)(C)C)C(C)(C)C

InChI

InChIKey=AGURKSYKTJQPNA-UHFFFAOYSA-N

InChI=1S/C26H44O2/c1-9-11-13-15-26(16-14-12-10-2)18-19-21(28-26)17-20(24(3,4)5)23(27)22(19)25(6,7)8/h17,27H,9-16,18H2,1-8H3

HIDE SMILES / InChI

Molecular Formula	C26H44O2
Molecular Weight	388.6264
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

PubMed

Title	Date	PubMed
Synthetic lipophilic antioxidant BO-653 suppresses HCV replication.	2013-02	23192857
Design, synthesis, and action of antiatherogenic antioxidants.	2010	20013174
Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation.	2008-04-01	18314329
Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.	2007-10-01	17706610
Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane.	2007-05	17476550
Cytotoxic effects of various stressors on PC12 cells: involvement of oxidative stress and effect of antioxidants.	2007-01	16942797
Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.	2006-09-01	16895792
Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid.	2006-03	16500556
Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE.	2005-10-01	16164964
The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion I: enhancing effects on oral bioavailability of poorly water soluble compounds in rats and beagle dogs.	2005-08	16141604
Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma.	2005-01-01	15589369
Inhibition of lipoprotein lipid oxidation.	2005	16596815
Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran.	2004-09-01	15294444
Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.	2003-07-03	12825946
BO-653. Chugai.	2003-03	12735236
Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.	2002-11	12592669
Effect of BO-653 and probucol on c-MYC and PDGF-A messenger RNA of the iliac artery after balloon denudation in cholesterol-fed rabbits.	2002-04	11888518
Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice.	2001	11686309

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:26:28 GMT 2025` Edited by `admin` on `Mon Mar 31 18:26:28 GMT 2025`
Record UNII	2VSP9T5LRX
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

4,6-BIS(1,1-DIMETHYLETHYL)-2,3-DIHYDRO-2,2-DIPENTYL-5-BENZOFURANOL

Preferred Name

English

BO-653

Code

English

5-BENZOFURANOL, 4,6-BIS(1,1-DIMETHYLETHYL)-2,3-DIHYDRO-2,2-DIPENTYL-

Systematic Name

English

Code System Code Type Description

FDA UNII

2VSP9T5LRX