TIBEGLISENE

Details

Stereochemistry	RACEMIC
Molecular Formula	C18H15ClO4S
Molecular Weight	362.827
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC=C(C=C1)S(=O)(=O)C(CC#CC2=CC=C(Cl)C=C2)C(O)=O

InChI

InChIKey=PZCCKADCRMBHIC-UHFFFAOYSA-N

InChI=1S/C18H15ClO4S/c1-13-5-11-16(12-6-13)24(22,23)17(18(20)21)4-2-3-14-7-9-15(19)10-8-14/h5-12,17H,4H2,1H3,(H,20,21)

HIDE SMILES / InChI

Molecular Formula	C18H15ClO4S
Molecular Weight	362.827
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2803236 | https://www.ncbi.nlm.nih.gov/pubmed/1939479

Tibeglisene (also known as BM 13907) is a pentynoic acid derivative patented by Boehringer Mannheim G.m.b.H. as insulin sensitizer with hypoglycemic activity. Tibeglisene is also able to reduce serum triglyceride and cholesterol concentrations. Tibeglisene exerts favor influences on glucose-transport activity.

Originator

Approval Year

PubMed

Title	Date	PubMed
Further evidence for a two-step model of glucose-transport regulation. Inositol phosphate-oligosaccharides regulate glucose-carrier activity.	1989 Aug 1	2803236

Patents

Sample Use Guides

In Vivo Use Guide

rat 100 mg/kg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:17:11 GMT 2023` Edited by `admin` on `Fri Dec 15 17:17:11 GMT 2023`
Record UNII	2U978AVF04
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TIBEGLISENE

Official Name

English

tibeglisene [INN]

Common Name

English

(±)-5-(P-CHLOROPHENYL)-2-(P-TOLYLSULFONYL)-4-PENTYNOIC ACID

Common Name

English

Code System Code Type Description

SMS_ID

100000082183