SM-934 FREE BASE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C17H29NO5
Molecular Weight	327.4159
Optical Activity	UNSPECIFIED
Defined Stereocenters	8 / 8
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H](OCCN)[C@@H]2C)O4

InChI

InChIKey=HPGHCIXRRLNXRN-XQLAAWPRSA-N

InChI=1S/C17H29NO5/c1-10-4-5-13-11(2)14(19-9-8-18)20-15-17(13)12(10)6-7-16(3,21-15)22-23-17/h10-15H,4-9,18H2,1-3H3/t10-,11-,12+,13+,14+,15-,16-,17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C17H29NO5
Molecular Weight	327.4159
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	8 / 8
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:03:59 GMT 2023` Edited by `admin` on `Sat Dec 16 17:03:59 GMT 2023`
Record UNII	2TF7EGV39I
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SM-934 FREE BASE

Common Name

English

.BETA.-AMINOARTEETHER

Common Name

English

2-(((3R,5AS,6R,8AS,9R,10S,12R,12AR)-DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL)OXY)ETHANAMINE

Systematic Name

English

ETHANAMINE, 2-((DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL)OXY)-, (3R-(3.ALPHA.,5A.BETA.,6.BETA.,8A.BETA.,9.ALPHA.,10.ALPHA.,12.BETA.,12AR*))-

Systematic Name

English

SM 934 FREE BASE

Code

English

ARTEETHER AMINE

Common Name

English

Code System Code Type Description

FDA UNII

2TF7EGV39I

Created by admin on Sat Dec 16 17:03:59 GMT 2023 , Edited by admin on Sat Dec 16 17:03:59 GMT 2023

PRIMARY

PUBCHEM

10019350

Created by admin on Sat Dec 16 17:03:59 GMT 2023 , Edited by admin on Sat Dec 16 17:03:59 GMT 2023

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MANUFACTURER PRODUCT INFORMATION

SM-934

Created by admin on Sat Dec 16 17:03:59 GMT 2023 , Edited by admin on Sat Dec 16 17:03:59 GMT 2023

PRIMARY

SM 934: CAS NO 133162-25-1For Autoimmune diseases, SLESM934, an artemisinin derivative, possesses potent antiproliferative and antiinflammatory properties

CAS

133162-24-0

Created by admin on Sat Dec 16 17:03:59 GMT 2023 , Edited by admin on Sat Dec 16 17:03:59 GMT 2023

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Related Record Type Details


					2TF7EGV39I

SM-934 FREE BASE

ACTIVE MOIETY

Comments:

RESULTS: In vitro, SM934 inhibited interferon-.GAMMA. (IFN.GAMMA.) and interleukin-17 (IL-17) production from polyclonal CD4+ T cells activated by T cell receptor engagement and the differentiation of naive CD4+ T cells into Th1 and Th17 cells, but not Treg cells. In vivo, 12-week-old MRL/lpr mice treated with SM934 for 4 weeks showed significantly ameliorated proteinuria and renal lesion severity, decreased levels of blood urea nitrogen, serum IFN.GAMMA., and serum anti-double-stranded DNA antibodies, decreased spleen size and a lower percentage of CD3+B220+CD4-CD8- T cells, 16-week-old MRL/lpr mice treated with SM934 for 8 weeks avoided severe proteinuria and survived longer. Ex vivo, SM934 treatment elevated the percentage of Treg cells, inhibited the development of Th1 and Th17 cells, and impeded the comprehensive activation of STAT-1, STAT-3, and STAT-5 proteins in splenocytes.

Amount: