RIDAZOLOL

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H18Cl2N4O3
Molecular Weight	373.234
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CNCCNC1=C(Cl)C(=O)NN=C1)COC2=C(Cl)C=CC=C2

InChI

InChIKey=UUWABVCZFXKHSU-UHFFFAOYSA-N

InChI=1S/C15H18Cl2N4O3/c16-11-3-1-2-4-13(11)24-9-10(22)7-18-5-6-19-12-8-20-21-15(23)14(12)17/h1-4,8,10,18,22H,5-7,9H2,(H2,19,21,23)

HIDE SMILES / InChI

Molecular Formula	C15H18Cl2N4O3
Molecular Weight	373.234
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2577285 | https://www.ncbi.nlm.nih.gov/pubmed/1353933 | https://adisinsight.springer.com/drugs/800000239

Ridazolol is a cardioselective and vasodilating beta-adrenergic receptor antagonist. It also has moderate alpha-adrenolytic activity (the presence of a heterogeneous population of postjunctional alpha adrenoceptors has been suggested). Ridazolol was investigated for use in arrhythmias and ischaemic heart disorders. In patients with confirmed coronary artery disease and reproducible ST-segment depression, blood pressure and heart rate under exercise were significantly reduced for 5 hours, and improvement of ST-segment depression lasted 1 hour. Ridazolol is well tolerated. This drug is not currently used.

Originator

Approval Year

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:11:17 GMT 2023` Edited by `admin` on `Fri Dec 15 16:11:17 GMT 2023`
Record UNII	2R4QO1868Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RIDAZOLOL

Official Name

English

ridazolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576