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Details

Stereochemistry ACHIRAL
Molecular Formula C13H18ClNO2
Molecular Weight 255.741
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CLOFOREX

SMILES

CCOC(=O)NC(C)(C)CC1=CC=C(Cl)C=C1

InChI

InChIKey=TZWKUQDQKPYNLL-UHFFFAOYSA-N
InChI=1S/C13H18ClNO2/c1-4-17-12(16)15-13(2,3)9-10-5-7-11(14)8-6-10/h5-8H,4,9H2,1-3H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula C13H18ClNO2
Molecular Weight 255.741
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Cloforex (Oberex) is an anorectic of the amphetamine class. It is a prodrug to chlorphentermine. It is an appetite-reducing agent, used to treat obesity. The Ministry of Health withdrew preparations containing cloforex as a precautionary measure pending scientific evidence of a relationship between their use and the development of pulmonary hypertension. In Europe Cloforex was approved in 1968 and discontinued in 1969.

Approval Year

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Oberex

PubMed

Sample Use Guides

In Vivo Use Guide
Rats - The anorectic drugs cloforex, at 3, 25, and 75 mg per kilogram of body weight, were administered daily by gavage to adult male white rats for up to 6 wk
Route of Administration: Enteral
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
2QJT5ZC1L6
Record Status Validated (UNII)
Record Version