CLOFOREX

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H18ClNO2
Molecular Weight	255.741
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)NC(C)(C)CC1=CC=C(Cl)C=C1

InChI

InChIKey=TZWKUQDQKPYNLL-UHFFFAOYSA-N

InChI=1S/C13H18ClNO2/c1-4-17-12(16)15-13(2,3)9-10-5-7-11(14)8-6-10/h5-8H,4,9H2,1-3H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula	C13H18ClNO2
Molecular Weight	255.741
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4862332
Curator's Comment: http://apps.who.int/medicinedocs/documents/s16780e/s16780e.pdf

Cloforex (Oberex) is an anorectic of the amphetamine class. It is a prodrug to chlorphentermine. It is an appetite-reducing agent, used to treat obesity. The Ministry of Health withdrew preparations containing cloforex as a precautionary measure pending scientific evidence of a relationship between their use and the development of pulmonary hypertension. In Europe Cloforex was approved in 1968 and discontinued in 1969.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Obesity 203 Sources: https://www.ncbi.nlm.nih.gov/pubmed/5743114 https://www.ncbi.nlm.nih.gov/pubmed/4862332	Primary		Approved 8429	Oberex Approved Use Obesity Launch Date -6.32448E10

PubMed

Title	Date	PubMed
[Oberex (Draco) cloforex].	1968 Mar 18	5743114
The distribution, elimination, and biotransformation of 14C-cloforex in the mouse and rat.	1970	5536739
Cloforex-induced pulmonary changes in rats.	1972 Apr	5050908

Patents

Sample Use Guides

In Vivo Use Guide

Rats - The anorectic drugs cloforex, at 3, 25, and 75 mg per kilogram of body weight, were administered daily by gavage to adult male white rats for up to 6 wk

Route of Administration: Enteral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:24:30 UTC 2023` Edited by `admin` on `Fri Dec 15 15:24:30 UTC 2023`
Record UNII	2QJT5ZC1L6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CLOFOREX

Official Name

English

D-237

Code

English

ETHYL (P-CHLORO-.ALPHA.,.ALPHA.-DIMETHYLPHENETHYL)CARBAMATE

Common Name

English

D 237

Code

English

CLOFOREX [MI]

Common Name

English

Cloforex [WHO-DD]

Common Name

English

cloforex [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29728