Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C15H10ClI2NO3 |
| Molecular Weight | 541.507 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(=O)OC1=C(C=C(I)C=C1I)C(=O)NC2=CC=C(Cl)C=C2
InChI
InChIKey=ICKMASVVMCGZLR-UHFFFAOYSA-N
InChI=1S/C15H10ClI2NO3/c1-8(20)22-14-12(6-10(17)7-13(14)18)15(21)19-11-4-2-9(16)3-5-11/h2-7H,1H3,(H,19,21)
| Molecular Formula | C15H10ClI2NO3 |
| Molecular Weight | 541.507 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Clioxanide is a derivative of diiodobenzanilide, developed by Parke, Davis & Co in the 1960s. It was used as an antihelmintic against Fasciola hepatica and Haemonchus contortus. In sheep, the compound was demonstrated high efficiency (greater than 90%) when administered at 20-40 mg/kg. Later it was found that clioxanide is an inhibitor of Type III Secretion in Yersinia bacteria.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Clioxanide, a new anthelmintic active against Fasciola hepatica and Haemonchus contortus in sheep. | 1970 Oct |
|
| Design, synthesis, and multivariate quantitative structure-activity relationship of salicylanilides--potent inhibitors of type III secretion in Yersinia. | 2007 Nov 29 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:24:29 GMT 2023
by
admin
on
Fri Dec 15 15:24:29 GMT 2023
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| Record UNII |
2Q9A409N0B
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| Record Status |
Validated (UNII)
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NCI_THESAURUS |
C250
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m655
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2484
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C65338
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238-414-0
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SUB06670MIG
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