OMALIZUMAB

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	2P471X1Z11
Record Status	`Validated (UNII)`
Record Version

Related Record	Type
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Name

Type

Language

OMALIZUMAB

Official Name

English

Omalizumab [WHO-DD]

Common Name

English

OMALIZUMAB [MART.]

Common Name

English

OMALIZUMAB (GENETICAL RECOMBINATION)

Official Name

English

OMALIZUMAB [PURPLE BOOK CDER]

Common Name

English

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Classification Tree

Code System

Code

Asthma

LIVERTOX

NBK548822

Established Pharmacologic Class

NDF-RT

N0000175794

Decreased Antibody Activity

NDF-RT

N0000175793

Decreased Antibody Activity

NDF-RT

N0000175793

SKIN DISEASES, VASCULAR

EMA ASSESSMENT REPORTS

XOLAIR(AUTHORIZED: ASTHMA, URTICARIA)

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Code System

Code

Type

Description

JAPANESE REVIEW

XOLAIR

PRIMARY

APPROVE JANUARY 2009

NCI_THESAURUS

C29299

PRIMARY

DAILYMED

2P471X1Z11

PRIMARY

INN

8039

PRIMARY

WIKIPEDIA

OMALIZUMAB

PRIMARY

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From	To
1_22	1_96
1_148	1_204
1_224	3_218
1_230	2_230
1_233	2_233

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Glycosylation Type

MAMMALIAN

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Glycosylation Link Type	Site
N	1_301
N	2_301

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Related Record

Type

Details

OMALIZUMAB BIOSIMILAR (CT-P39)

SUB_CONCEPT->SUBSTANCE

Amount:


					AF59OKU9U8

IMMUNOGLOBULIN E HEAVY CHAIN CONSTANT REGION

TARGET -> INHIBITOR

Comments:

Omalizumab inhibits the binding of IgE to FcεRI on mast cells and basophils by binding to an antigenic epitope on IgE that overlaps with the site to which FcεRI binds.

Interaction Type:

BINDING

Amount:

SYN-008

SUB_CONCEPT->SUBSTANCE

Amount:

GBR-310

SUB_CONCEPT->SUBSTANCE

Amount:

GBR-310

BIOSIMILAR -> PARENT

Amount:

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Related Record

Type

Details


					2P471X1Z11

OMALIZUMAB

ACTIVE MOIETY

Amount:

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6504H9976N1732O2046S42
MOL_WEIGHT	CHEMICAL	149171 Da (average)

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