AMEDALIN

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H22N2O
Molecular Weight	294.3908
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCCC1(C)C(=O)N(C2=CC=CC=C12)C3=CC=CC=C3

InChI

InChIKey=HBGWAZBZXJBYQD-UHFFFAOYSA-N

InChI=1S/C19H22N2O/c1-19(13-8-14-20-2)16-11-6-7-12-17(16)21(18(19)22)15-9-4-3-5-10-15/h3-7,9-12,20H,8,13-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C19H22N2O
Molecular Weight	294.3908
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26051466 | https://www.drugbank.ca/drugs/DB09188 | https://www.ncbi.nlm.nih.gov/pubmed/4977402

Amedalin (UK-3540) is a selective norepinephrine reuptake inhibitor developed in the 1970s. Amedalin was a potential antidepressant compound. It has no significant effect on reuptake of serotonin and dopamine and no antihistamine or anticholinergic properties. This drug was never marketed.

CNS Activity

Approval Year

PubMed

Title	Date	PubMed
UK-3540: a preliminary evaluation of a potential antidepressant compound: animal and human correlations.	1969 May	4977402
Central Nervous System Activities of Indole Derivatives: An Overview.	2015	26051466

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:10:26 UTC 2023` Edited by `admin` on `Fri Dec 15 16:10:26 UTC 2023`
Record UNII	2OWK6X9N16
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMEDALIN

Official Name

English

3-METHYL-3-(3-(METHYLAMINO)PROPYL)-1-PHENYL-2-INDOLINONE

Systematic Name

English

amedalin [INN]

Common Name

English

2H-INDOL-2-ONE, 1,3-DIHYDRO-3-METHYL-3-(3-(METHYLAMINO)PROPYL)-1-PHENYL-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C265