ISOXEPAC

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H12O4
Molecular Weight	268.2641
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)CC1=CC=C2OCC3=CC=CC=C3C(=O)C2=C1

InChI

InChIKey=QFGMXJOBTNZHEL-UHFFFAOYSA-N

InChI=1S/C16H12O4/c17-15(18)8-10-5-6-14-13(7-10)16(19)12-4-2-1-3-11(12)9-20-14/h1-7H,8-9H2,(H,17,18)

HIDE SMILES / InChI

Molecular Formula	C16H12O4
Molecular Weight	268.2641
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7013009 | https://www.ncbi.nlm.nih.gov/pubmed/7040500

Isoxepac (also known) as HP-549 is a non-steroidal anti-inflammatory drug with analgesic activity. Isoxepac was studied in the clinical trial for the treatment of postoperative pain after knee surgery for meniscectomy. It was shown, that 200 mg of isoxepac would appear to be the minimal effective dose. In case of rheumatoid arthritis, isoxepac showed significantly fewer adverse effects.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 320 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7013009	Palliative		Not Provided 511	Unknown Approved Use Unknown
Postmeniscectomy pain 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/7040500	Primary		Not Provided 511	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Analgesic effect of isoxepac on postmeniscectomy pain: a controlled trial.	1982-02-01	7040500
Local buccal mucosal effects of aspirin, indomethacin and isoxepac: their relationship to gastrointestinal damage.	1981-05	7272169
Isoxepac in rheumatoid arthritis: a double-blind comparison with aspirin.	1981-02-01	7013009
Quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e] oxepin-2-acetic acid (isoxepac) in plasma and urine by gas--liquid chromatography.	1978-05-01	659525

Patents

Sample Use Guides

In Vivo Use Guide

rheumatoid arthritis: 200 mg three times daily

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:44:55 GMT 2025` Edited by `admin` on `Mon Mar 31 18:44:55 GMT 2025`
Record UNII	2KH283Q0Z5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISOXEPAC

Official Name

English

OLOPATADINE RELATED COMPOUND C

Preferred Name

English

HP 549

Code

English

isoxepac [INN]

Common Name

English

ISOXEPAC [USAN]

Common Name

English

OLOPATADINE RELATED COMPOUND C [USP IMPURITY]

Common Name

English

P 720549

Code

English

6,11-Dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid

Systematic Name

English

ARTIL

Brand Name

English

HP-549

Code

English

NSC-300907

Code

English

OLOPATADINE RELATED COMPOUND C [USP-RS]

Common Name

English

ISOXEPAC [MI]

Common Name

English

DIBENZ(B,E)OXEPIN-2-ACETIC ACID, 6,11-DIHYDRO-11-OXO-

Common Name

English

P-720549

Code

English

Code System Code Type Description

RS_ITEM_NUM

1478436