U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C13H17NO2
Molecular Weight 219.2796
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALMINOPROFEN, (S)-

SMILES

C[C@H](C(O)=O)C1=CC=C(NCC(C)=C)C=C1

InChI

InChIKey=FPHLBGOJWPEVME-JTQLQIEISA-N
InChI=1S/C13H17NO2/c1-9(2)8-14-12-6-4-11(5-7-12)10(3)13(15)16/h4-7,10,14H,1,8H2,2-3H3,(H,15,16)/t10-/m0/s1

HIDE SMILES / InChI
Molecular Formula C13H17NO2
Molecular Weight 219.2796
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/2787705

Alminoprofen is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylpropionic acid class. It has anti-inflammatory properties different from the classical NSAID. Alminoprofen possesses both antiphospholipase A2 (PLA2) activity and anti-cycloxygenase (COX) activity.

CNS Activity

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Secretory phospholipase A2, Homo sapiens
3
Target ID: Secretory phospholipase A2, Homo sapiens
Inhibitor
8297
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
Minalfen

Approved Use

Indications: inflammation, pain
Primary
Approved
8429
Minalfen

Approved Use

Indications: inflammation, pain
PubMed

PubMed

TitleDatePubMed
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Patents

Patents

US2016089478
3
US2016090381
3

Sample Use Guides

In Vivo Use Guide
In rheumatoid arthritis and spondylosis deformans - 200 mg (three times a day) repeated dose for 5 days.
Route of Administration: Oral
In Vitro Use Guide
Alminoprofen (10(-6)-10(-4) M) inhibited dose-dependently the chemotaxis of leukocytes induced by chemotactic factors from guinea pig neutrophils stimulated with sodium urate crystals.
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:37:12 GMT 2023
Edited
by admin
on Fri Dec 15 19:37:12 GMT 2023
Record UNII
2K06B7892T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALMINOPROFEN, (S)-
Common Name English
ALMINOPROFEN, (+)-
Common Name English
BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPEN-1-YL)AMINO)-, (+)-
Systematic Name English
BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPENYL)AMINO)-, (+)-
Common Name English
BENZENEACETIC ACID, .ALPHA.-METHYL-4-((2-METHYL-2-PROPEN-1-YL)AMINO)-, (.ALPHA.S)-
Systematic Name English
(+)-ALMINOPROFEN
Common Name English
D-ALMINOPROFEN
Common Name English
Code System Code Type Description
CAS
71589-39-4
Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023
PRIMARY
PUBCHEM
69305006
Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023
PRIMARY
EPA CompTox
DTXSID801167057
Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023
PRIMARY
FDA UNII
2K06B7892T
Created by admin on Fri Dec 15 19:37:12 GMT 2023 , Edited by admin on Fri Dec 15 19:37:12 GMT 2023
PRIMARY
Related Record Type Details
Structure of ALMINOPROFEN
RACEMATE -> ENANTIOMER
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966