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Details

Stereochemistry RACEMIC
Molecular Formula C19H23NO2S
Molecular Weight 329.456
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEPROTIXOL

SMILES

COC1=CC2=C(SC3=CC=CC=C3C2(O)CCCN(C)C)C=C1

InChI

InChIKey=LAYVFLWAVIGDLK-UHFFFAOYSA-N
InChI=1S/C19H23NO2S/c1-20(2)12-6-11-19(21)15-7-4-5-8-17(15)23-18-10-9-14(22-3)13-16(18)19/h4-5,7-10,13,21H,6,11-12H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C19H23NO2S
Molecular Weight 329.456
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Meprotixol is a thiaxanthene derivative. Meprotixol revealed a potent antitussive activity. It has slight central depressive effect. Meprotixol reduces the spontaneous motor activity of mice, but its potency is negligible in comparison with those of neuroleptics such as chlorpromazine and chlorprothixene. Meprotixol in suitable doses reduces the quantity of barbiturate required to secure anesthesia. Meprotixol showed a potent broncho-spasmolytic effect against 5-hydroxytryptamine spasms in guinea pigs. This compound has a marked inhibitory effect against various forms of edema and exudation in the granuloma pouch, though the inhibition of granuloma formation was only slight. Phenylbutazone seemed to be more effective than meprotixol in the treatment of rheumatic disease.

Approval Year

Sample Use Guides

10 mg 3 times a day
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:46:29 GMT 2023
Edited
by admin
on Fri Dec 15 16:46:29 GMT 2023
Record UNII
2JXZ154Z0Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEPROTIXOL
INN   WHO-DD  
INN  
Official Name English
Meprotixol [WHO-DD]
Common Name English
MEPROTHIXOL
Common Name English
N-7020
Code English
meprotixol [INN]
Common Name English
9H-THIOXANTHEN-9-OL, 9-(3-(DIMETHYLAMINO)PROPYL)-2-METHOXY-
Systematic Name English
9-(3-(DIMETHYLAMINO)PROPYL)-2-METHOXY-THIOXANTHENE-9-OL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C66917
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
WHO-ATC R05DB22
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
WHO-VATC QR05DB22
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C87660
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
EVMPD
SUB08759MIG
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
DRUG CENTRAL
4656
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
WIKIPEDIA
MEPROTIXOL
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
INN
1569
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
CAS
4295-63-0
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
PUBCHEM
71195
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
FDA UNII
2JXZ154Z0Q
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105167
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
EPA CompTox
DTXSID40863358
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
DRUG BANK
DB13822
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
SMS_ID
100000081481
Created by admin on Fri Dec 15 16:46:29 GMT 2023 , Edited by admin on Fri Dec 15 16:46:29 GMT 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
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ACTIVE MOIETY