Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H23NO2S |
Molecular Weight | 329.456 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(SC3=CC=CC=C3C2(O)CCCN(C)C)C=C1
InChI
InChIKey=LAYVFLWAVIGDLK-UHFFFAOYSA-N
InChI=1S/C19H23NO2S/c1-20(2)12-6-11-19(21)15-7-4-5-8-17(15)23-18-10-9-14(22-3)13-16(18)19/h4-5,7-10,13,21H,6,11-12H2,1-3H3
Molecular Formula | C19H23NO2S |
Molecular Weight | 329.456 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Meprotixol is a thiaxanthene derivative. Meprotixol revealed a potent antitussive activity. It has slight central depressive effect. Meprotixol reduces the spontaneous motor activity of mice, but its potency is negligible in comparison with those of neuroleptics such as chlorpromazine and chlorprothixene. Meprotixol in suitable doses reduces the quantity of barbiturate required to secure anesthesia. Meprotixol showed a potent broncho-spasmolytic effect against 5-hydroxytryptamine spasms in guinea pigs. This compound has a marked inhibitory effect against various forms of edema and exudation in the granuloma pouch, though the inhibition of granuloma formation was only slight. Phenylbutazone seemed to be more effective than meprotixol in the treatment of rheumatic disease.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/5338050
10 mg 3 times a day
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:46:29 GMT 2023
by
admin
on
Fri Dec 15 16:46:29 GMT 2023
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Record UNII |
2JXZ154Z0Q
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C66917
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WHO-ATC |
R05DB22
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WHO-VATC |
QR05DB22
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C87660
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SUB08759MIG
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4656
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MEPROTIXOL
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1569
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4295-63-0
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71195
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2JXZ154Z0Q
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CHEMBL2105167
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DTXSID40863358
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DB13822
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100000081481
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PRIMARY |
Related Record | Type | Details | ||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |