SCH-486757

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H23Cl2N3O
Molecular Weight	440.365
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@]1(C[C@@H]2CC[C@H](C1)N2C(C3=CC=CC=C3Cl)C4=CC=CC=C4Cl)C5=NC=CC=N5

InChI

InChIKey=MQWMHMZNBGQNMT-XHNJZIHCSA-N

InChI=1S/C24H23Cl2N3O/c25-20-8-3-1-6-18(20)22(19-7-2-4-9-21(19)26)29-16-10-11-17(29)15-24(30,14-16)23-27-12-5-13-28-23/h1-9,12-13,16-17,22,30H,10-11,14-15H2/t16-,17+,24-

HIDE SMILES / InChI

Molecular Formula	C24H23Cl2N3O
Molecular Weight	440.365
Charge	0
Count

Stereochemistry	EPIMERIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19937046 | https://adisinsight.springer.com/drugs/800038184

SCH486757 was invented as a selective nociceptin/orphanin FQ peptide (NOP) receptor agonist. SCH486757 participated in phase II clinical trial for the treatment of cough, however, this study was discontinued.

Approval Year

PubMed

Title	Date	PubMed
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.	2010 Mar 25	20006596
Regulating cough through modulation of sensory nerve function in the airways.	2013 Oct	23524012

Sample Use Guides

In Vivo Use Guide

Subjects were randomised to receive either SCH486757 100 mg, codeine 30 mg, or matched placebo twice daily for 5 days

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:01:40 GMT 2023` Edited by `admin` on `Sat Dec 16 03:01:40 GMT 2023`
Record UNII	2HV668N62T
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SCH-486757

Common Name

English

SCH486757

Code

English

SCH 486757

Code

English

8-AZABICYCLO(3.2.1)OCTAN-3-OL, 8-(BIS(2-CHLOROPHENYL)METHYL)-3-(2-PYRIMIDINYL)-

Systematic Name

English

Code System Code Type Description

PUBCHEM

11597355