MORINAMIDE HYDROCHLORIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H14N4O2.ClH
Molecular Weight	258.705
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.O=C(NCN1CCOCC1)C2=NC=CN=C2

InChI

InChIKey=CQTFUUAUHIMFAJ-UHFFFAOYSA-N

InChI=1S/C10H14N4O2.ClH/c15-10(9-7-11-1-2-12-9)13-8-14-3-5-16-6-4-14;/h1-2,7H,3-6,8H2,(H,13,15);1H

HIDE SMILES / InChI

Molecular Formula	C10H14N4O2
Molecular Weight	222.2438
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4953657 | https://www.ncbi.nlm.nih.gov/pubmed/9007735 | http://en.pharmacodia.com/web/drug/1_11056.html | https://www.ncbi.nlm.nih.gov/pubmed/10864178

Morinamide is a second line anti-tuberculous agent. In vitro morinamide demonstrated clear dose-dependent bacteriostatic and bactericidal activities. The anti-mycobacterial effect of morinamide was the same as pyrazinamide and was dependent on the acidity of medium (pH 5.6). Liver function test abnormalities following morinamide therapy are usually mild, and onset of jaundice is extremely uncommon. It has been given orally as the hydrochloride in the treatment of tuberculosis.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Tuberculosis 83 Sources: http://en.pharmacodia.com/web/drug/1_11056.html https://www.ncbi.nlm.nih.gov/pubmed/5322284 https://www.ncbi.nlm.nih.gov/pubmed/5322283	Curative		Approved 8583	Piazofolina Approved Use Unknown Launch Date 1991

PubMed

Title	Date	PubMed
New agents active against Mycobacterium avium complex selected by molecular topology: a virtual screening method.	2004-01	14645324
[On therapeutic effects of morphazinamide, used alone and in association, in recent and chronic pulmonary tuberculosis].	1965-09-05	5322267
[Clinical findings on curative action of morphazinamide, administered intravenously, to patients with pulmonary tuberculosis].	1965-09-05	5322268
[Clinical experiences with morphazinamide administered in slow venous perfusion in the treatment of pulmonary tuberculosis].	1965-09-05	5322269
[Intravenous morphazinamide. Tolerance of the drug and therapeutic effects].	1965-09-05	5322270
[Morphazinamide in antitubercular therapy. 2 years of clinical experimentation].	1965-09-05	5322272
[Clinical experience with morphazinamide].	1965-09-05	5322273
[Clinical research on the use of morphazinamide in pulmonary tuberculosis].	1965-09-05	5322274
[Morphazinamide by venous perfusion in therapy of pulmonary tuberculosis].	1965-09-05	5322275
[Clinical observations on morphazinamide administered by intravenous perfusion in therapy of pulmonary tuberculosis].	1965-09-05	5322276
[Behavior of some hematochemical data and of the most important biological indexes of disease and of phase in subjects affected by pulmonary tuberculosis treated with morphazinamide].	1965-09-01	5322265
[Morphazinamide in the treatment of urinary tuberculosis].	1965-09-01	5322266

Patents

Sample Use Guides

In Vivo Use Guide

Mice: 500 mg/kg every day for a period of 20 weeks.

Route of Administration: Other

In Vitro Use Guide

Monocytes separated from human blood were incubated in plastic plates for seven days to mature into macrophage monolayers. After activation with TNF-alpha or IFN-gamma or without prior treatment, the macrophages were infected with M. tuberculosis. Morinamide exhibited a very clear dose-dependent bacteriostatic and bactericidal effect in experiments with ‘normal’ macrophages at concentrations 64, 128 and 256 ug/ml.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 19:17:22 GMT 2025` Edited by `admin` on `Mon Mar 31 19:17:22 GMT 2025`
Record UNII	2F6F46T9YC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MORINAMIDE HYDROCHLORIDE

Common Name

English

MORPHAZINAMIDE HYDROCHLORIDE

Preferred Name

English

PIAZOFOLINA

Brand Name

English

MORINAMIDE HCL

Common Name

English

B-2311

Code

English

Morinamide hydrochloride [WHO-DD]

Common Name

English

2-PYRAZINECARBOXAMIDE, N-(4-MORPHOLINYLMETHYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

MORPHAZINAMIDE HYDROCHLORIDE [MI]

Common Name

English

Code System Code Type Description

EVMPD

SUB03330MIG