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Details

Stereochemistry ACHIRAL
Molecular Formula C22H19N5O2
Molecular Weight 385.4186
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ACUMAPIMOD

SMILES

CC1=CC=C(C=C1N2N=CC(C(=O)C3=CC=CC(=C3)C#N)=C2N)C(=O)NC4CC4

InChI

InChIKey=VGUSQKZDZHAAEE-UHFFFAOYSA-N
InChI=1S/C22H19N5O2/c1-13-5-6-16(22(29)26-17-7-8-17)10-19(13)27-21(24)18(12-25-27)20(28)15-4-2-3-14(9-15)11-23/h2-6,9-10,12,17H,7-8,24H2,1H3,(H,26,29)

HIDE SMILES / InChI

Molecular Formula C22H19N5O2
Molecular Weight 385.4186
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Acumapimod (BCT-197) is an oral p38 MAP kinase inhibitor and an anti-inflammatory agent developed by Mereo BioPharma that has completed Phase 2 development as first-line therapy for severe acute exacerbations of chronic obstructive pulmonary disease. Another study on acute kidney injury in patients undergoing cardiac surgery had been discontinued. Acumapimod is an inhibitor of p38a with an IC50 value < 1 uM. Previous studies undertaken by Novartis, showed the drug has the capacity to reduce the inflammatory marker TNFα and to increase FEV1.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: LPS‐induced TNFα secretion
115.0 nM [IC50]
12.0 nM [IC50]
PubMed

PubMed

TitleDatePubMed
Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
2015 Mar
Patents

Sample Use Guides

The effects of single doses of 20 and 75 mg acumapimod ± prednisone, were investigated in COPD patients
Route of Administration: Oral
Acumapimod is an inhibitor of p38a with an IC50 value < 1 uM.
Substance Class Chemical
Created
by admin
on Sat Dec 16 08:28:07 UTC 2023
Edited
by admin
on Sat Dec 16 08:28:07 UTC 2023
Record UNII
2F16KW647L
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ACUMAPIMOD
INN   WHO-DD  
INN  
Official Name English
BENZAMIDE, 3-(5-AMINO-4-(3-CYANOBENZOYL)-1H-PYRAZOL-1-YL)-N-CYCLOPROPYL-4-METHYL-
Systematic Name English
Acumapimod [WHO-DD]
Common Name English
acumapimod [INN]
Common Name English
3-(5-AMINO-4-(3-CYANOBENZOYL)PYRAZOL-1-YL)-N-CYCLOPROPYL-4-METHYLBENZAMIDE
Systematic Name English
Code System Code Type Description
PUBCHEM
11338127
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
DRUG BANK
DB15448
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
SMS_ID
300000025633
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
NCI_THESAURUS
C166567
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
CAS
836683-15-9
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
ChEMBL
CHEMBL3545226
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
FDA UNII
2F16KW647L
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
INN
9917
Created by admin on Sat Dec 16 08:28:07 UTC 2023 , Edited by admin on Sat Dec 16 08:28:07 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY