Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H47N3O9S |
| Molecular Weight | 625.774 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 4 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
InChI
InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
| Molecular Formula | C30H47N3O9S |
| Molecular Weight | 625.774 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 4 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Accumulation of leukotriene C4 and histamine in human allergic skin reactions. | 1985 Aug |
|
| [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker]. | 1990 Feb |
|
| Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991 Apr |
|
| Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips. | 1991 Mar 26 |
|
| Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993 Dec |
|
| Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996 Nov |
|
| Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. | 1997 Dec 1 |
|
| Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | 1997 Oct 15 |
|
| Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998 Apr |
|
| A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma. | 2000 Jun |
|
| Characterization of the human cysteinyl leukotriene 2 receptor. | 2000 Sep 29 |
|
| Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. | 2001 Jan |
|
| Molecular cloning and functional characterization of murine cysteinyl-leukotriene 1 (CysLT(1)) receptors. | 2001 Nov 1 |
|
| Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity. | 2001 Oct 12 |
|
| Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). | 2002 May 10 |
|
| Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. | 2003 Sep |
|
| The human multidrug-resistance-associated protein MRP1 mediates ATP-dependent transport of unconjugated bilirubin. | 2004 Oct 15 |
|
| Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007 Feb |
|
| Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. | 2011 Oct |
|
| Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012 Mar 2 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:06:40 GMT 2023
by
admin
on
Fri Dec 15 15:06:40 GMT 2023
|
| Record UNII |
2CU6TT9V48
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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5280493
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2CU6TT9V48
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57973
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LEUKOTRIENE C4
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m6777
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D017997
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DTXSID00903946
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16978
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DB08855
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72025-60-6
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