Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C30H47N3O9S |
| Molecular Weight | 625.774 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 4 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O
InChI
InChIKey=GWNVDXQDILPJIG-NXOLIXFESA-N
InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
| Molecular Formula | C30H47N3O9S |
| Molecular Weight | 625.774 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 4 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. | 2015-02 |
|
| Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1). | 2012-03-02 |
|
| Synthesis of cysteinyl leukotrienes in human endothelial cells: subcellular localization and autocrine signaling through the CysLT2 receptor. | 2011-10 |
|
| Active transport of contact allergens in human monocyte-derived dendritic cells is mediated by multidrug resistance related proteins. | 2011-04-15 |
|
| Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays. | 2011-02 |
|
| Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. | 2010-12-01 |
|
| 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38 MAPK. | 2010-01-15 |
|
| The influence of tumor necrosis factor alpha (TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle. | 2008-11 |
|
| Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter. | 2008-04-15 |
|
| The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. | 2008 |
|
| Multidrug resistance protein 1 (MRP1) in rabbit conjunctival epithelial cells: its effect on drug efflux and its regulation by adenoviral infection. | 2007-08 |
|
| Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1). | 2007-02 |
|
| Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism. | 2006-10 |
|
| Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers. | 1999-01-22 |
|
| Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. | 1998-06-18 |
|
| Adenosine triphosphate-dependent transport of anionic conjugates by the rabbit multidrug resistance-associated protein Mrp2 expressed in insect cells. | 1998-06 |
|
| Urinary trypsin inhibitor reduces the release of histamine from rat peritoneal mast cells. | 1998-04 |
|
| Identification and characterization of two cysteinyl-leukotriene high affinity binding sites with receptor characteristics in human lung parenchyma. | 1998-04 |
|
| Characteristics of arachidonic acid generation in human basophils: relationship between the effects of inhibitors of secretory phospholipase A2 activity and leukotriene C4 release. | 1998-03 |
|
| Capacity for repeatable leukotriene generation after transient stimulation of mast cells and macrophages. | 1998-02-01 |
|
| Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver. | 1998-01-16 |
|
| Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. | 1998 |
|
| Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. | 1997-12-01 |
|
| Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. | 1997-10-15 |
|
| Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. | 1997-05-05 |
|
| Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism. | 1997-05 |
|
| Pharmacological modulation of human platelet leukotriene C4-synthase. | 1997-03-21 |
|
| Leukotriene C4 from vascular endothelium enhances neutrophil adhesiveness. | 1997-02 |
|
| Mast cell effector mechanisms. | 1996-11 |
|
| Increased biliary secretion of cysteinyl-leukotrienes in human bile duct obstruction. | 1996-11 |
|
| Effects of leukotriene C4 and D4, histamine and bradykinin on cytosolic calcium concentrations and adhesiveness of endothelial cells and neutrophils. | 1996-03 |
|
| Lipoxin A4 receptor activation is distinct from that of the formyl peptide receptor in myeloid cells: inhibition of CD11/18 expression by lipoxin A4-lipoxin A4 receptor interaction. | 1995-12-26 |
|
| Fecal excretion of leukotriene C4 during human disease due to Shigella dysenteriae. | 1995-02 |
|
| The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. | 1994-11-11 |
|
| Identification of a human cDNA encoding a functional high affinity lipoxin A4 receptor. | 1994-07-01 |
|
| Effect of the leukotriene receptor antagonist MK-0679 on baseline pulmonary function in aspirin sensitive asthmatic subjects. | 1993-12 |
|
| Effect of preoperative i.m. administration of diclofenac on suxamethonium-induced myalgia. | 1993-08 |
|
| Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung. | 1993-02-15 |
|
| Immunoaffinity purification of prostaglandin E2 and leukotriene C4 prior to radioimmunoassay: application to human synovial fluid. | 1993-01 |
|
| Transcardiac release of leukotriene C4 by neutrophils in patients with coronary artery disease. | 1991-04 |
|
| [Responses of plasma eicosanoids and hemodynamics to myocardial ischemia and the salutary effect of calcium entry blocker]. | 1990-02 |
|
| [Leukotriene B4, leukotriene C4 and prostaglandin E2 in the serum, synovial fluid and synovium in patients with rheumatoid arthritis]. | 1989-12 |
|
| The role of acupuncture in asthma: changes in airways dynamics and LTC4 induced LAI. | 1989 |
|
| Enhanced leukotriene C4 production by peripheral eosinophilic granulocytes from children with asthma. | 1989 |
|
| Cellular communication in leukotriene C4 production between eosinophils and neutrophils. | 1989 |
|
| CSF leukotriene C4 following subarachnoid hemorrhage. | 1988-10 |
|
| Increased amniotic fluid leukotriene C4 concentration in term human parturition. | 1988-09 |
|
| [Quantitative evaluation of conjunctival irritation by simultaneous determination of histamine, serotonin and leukotriene C4 in tears]. | 1987-10-01 |
|
| Accumulation of leukotriene C4 and histamine in human allergic skin reactions. | 1985-08 |
|
| Influence of leukotriene C4 on aggregation and on malondialdehyde formation of human blood platelets. | 1984 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:46:48 GMT 2025
by
admin
on
Mon Mar 31 17:46:48 GMT 2025
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| Record UNII |
2CU6TT9V48
|
| Record Status |
Validated (UNII)
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| Record Version |
|
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5280493
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2CU6TT9V48
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57973
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LEUKOTRIENE C4
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m6777
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D017997
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DTXSID00903946
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16978
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DB08855
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72025-60-6
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