PAZELLIPTINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H27N5
Molecular Weight	361.4833
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCCNC1=NC=CC2=C(C)C3=C(C=C12)C4=CN=CC=C4N3

InChI

InChIKey=LPHSYQSMAGVYNT-UHFFFAOYSA-N

InChI=1S/C22H27N5/c1-4-27(5-2)12-6-9-24-22-18-13-17-19-14-23-10-8-20(19)26-21(17)15(3)16(18)7-11-25-22/h7-8,10-11,13-14,26H,4-6,9,12H2,1-3H3,(H,24,25)

HIDE SMILES / InChI

Molecular Formula	C22H27N5
Molecular Weight	361.4833
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2830964 | https://www.ncbi.nlm.nih.gov/pubmed/9463113 | https://adisinsight.springer.com/drugs/800004215

Pazelliptine (previously known as BD 40 or SR 95225A) was developed as an antitumor drug that binds to the DNA sequence, preferable to G-C rich region and thus produces cellular DNA lesions. This drug was undergoing phase II trials in France for the treatment of cancer. However, this study was discontinued.

Approval Year

PubMed

Title	Date	PubMed
Possible relationship between pyrido-pyrrolo-isoquinoline derivative (BD-40) cell uptake and cell viability.	1982 Oct	6817823
Likelihood of the new antitumoral drug 10-[gamma-diethylaminopropylamino]-6-methyl-5H-pyrido[3',4':4,5]pyrrolo [2,3-g]isoquinoline (BD-40), a pyridopyrroloisoquinoline derivative, to induce DNA strand breaks in vivo and its nonmutagenicity in yeast.	1983 Aug	6344990
Production of protein-associated DNA breaks by 10-[diethylaminopropylamino]-6-methyl-5H-pyrido[3',4':4,5]pyrrolo [2,3-g]isoquinoline in cultured L1210 cells and in isolated nuclei: comparison with other topoisomerase II inhibitors.	1988 Mar 15	2830964
Spectroscopic study of the interaction of pazelliptine with nucleic acids.	1997 Oct	9463113

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:26:49 GMT 2023` Edited by `admin` on `Fri Dec 15 16:26:49 GMT 2023`
Record UNII	2CSP4U82HK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PAZELLIPTINE

Official Name

English

SR 95225

Code

English

SR-95225

Code

English

PAZELLIPTICINE

Common Name

English

10-((3-(DIETHYLAMINO)PROPYL)AMINO)-6-METHYL-5H-PYRIDO(3',4':4,5)PYRROLO(2,3-G)ISOQUINOLINE

Systematic Name

English

pazelliptine [INN]

Common Name

English

NSC-303565

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C582