LOVOTIBEGLOGENE AUTOTEMCEL

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:18:53 GMT 2023` Edited by `admin` on `Sat Dec 16 18:18:53 GMT 2023`
Source Materials Class	ORGANISM
Source Materials Type	AUTOLOGOUS HUMAN
Source Materials State	LIVE GENETICALLY MODIFIED
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	BONE MARROW
Fraction Material Type	CELLS
Fraction Name	hematopoietic stem and progenitor cells (patients with sickle cell disease)
Record UNII	2C6A9NH2Z8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOVOTIBEGLOGENE AUTOTEMCEL

Official Name

English

lovotibeglogene autotemcel [INN]

Common Name

English

LOVOTIBEGLOGENE AUTOTEMCEL [USAN]

Common Name

English

AUTOLOGOUS CD34+ CELLS ENCODING .BETA.A-T87Q-GLOBIN GENE (PATIENTS WITH SICKLE CELL DISEASE)

Common Name

English

BB-1111

Code

English

AN AUTOLOGOUS CD34+ CELL-ENRICHED POPULATION FROM PATIENTS WITH SICKLE CELL DISEASE THAT CONTAINS HEMATOPOIETIC STEM CELLS TRANSDUCED WITH BB305 LENTIVIRAL VECTOR ENCODING THE .BETA.A-T87Q-GLOBIN GENE

Common Name

English

BB1111

Code

English

Code System Code Type Description

USAN

HI-143

Created by admin on Sat Dec 16 18:18:53 GMT 2023 , Edited by admin on Sat Dec 16 18:18:53 GMT 2023

PRIMARY

NCI_THESAURUS

C176855

Created by admin on Sat Dec 16 18:18:53 GMT 2023 , Edited by admin on Sat Dec 16 18:18:53 GMT 2023

PRIMARY

INN

11826

Created by admin on Sat Dec 16 18:18:53 GMT 2023 , Edited by admin on Sat Dec 16 18:18:53 GMT 2023

PRIMARY

FDA UNII

2C6A9NH2Z8

Created by admin on Sat Dec 16 18:18:53 GMT 2023 , Edited by admin on Sat Dec 16 18:18:53 GMT 2023

PRIMARY

Related Record Type Details


					2C6A9NH2Z8

LOVOTIBEGLOGENE AUTOTEMCEL

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Type	Fragment Name	Fragment ID
CD34+ Cell Labeling	IMMUNOLOGICAL
	LENTIVIRAL TRANSFECTION	BETIBEGLOGENE DAROLENTIVEC	7VEJ4HT24J
CD34+ Enrichment	CELL SEPARATION

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
VECTOR EXPRESSED PROTEIN					UNSPECIFIED SUBSTANCE	f4353dfd (not in database)
INSERTED GENE EXPRESSION VECTOR					UNSPECIFIED SUBSTANCE	53ad4970 (not in database)

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
ANTIGEN EXPRESSED	BIOLOGICAL		`ZWL6BH0E0S` HEMATOPOIETIC PROGENITOR CELL ANTIGEN CD34