U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Structurally Diverse
Created
by admin
on Wed Apr 02 10:41:03 GMT 2025
Edited
by admin
on Wed Apr 02 10:41:03 GMT 2025
Source Materials Class ORGANISM
Source Materials Type AUTOLOGOUS HUMAN
Source Materials State LIVE GENETICALLY MODIFIED
Source Materials Parent
Part mobilised peripheral blood, from patients with sickle cell disease
Fraction Material Type cells
Fraction Name hematopoietic stem and progenitor cells (patients with sickle cell disease)
Record UNII
2C6A9NH2Z8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BB-1111
Preferred Name English
LOVOTIBEGLOGENE AUTOTEMCEL
USAN   INN  
Official Name English
lovotibeglogene autotemcel [INN]
Common Name English
LOVOTIBEGLOGENE AUTOTEMCEL [USAN]
Common Name English
AUTOLOGOUS CD34+ CELLS ENCODING .BETA.A-T87Q-GLOBIN GENE (PATIENTS WITH SICKLE CELL DISEASE)
Common Name English
Lovotibeglogene autotemcel [WHO-DD]
Common Name English
AN AUTOLOGOUS CD34+ CELL-ENRICHED POPULATION FROM PATIENTS WITH SICKLE CELL DISEASE THAT CONTAINS HEMATOPOIETIC STEM CELLS TRANSDUCED WITH BB305 LENTIVIRAL VECTOR ENCODING THE .BETA.A-T87Q-GLOBIN GENE
Common Name English
BB1111
Code English
Code System Code Type Description
USAN
HI-143
Created by admin on Wed Apr 02 10:41:03 GMT 2025 , Edited by admin on Wed Apr 02 10:41:03 GMT 2025
PRIMARY
NCI_THESAURUS
C176855
Created by admin on Wed Apr 02 10:41:03 GMT 2025 , Edited by admin on Wed Apr 02 10:41:03 GMT 2025
PRIMARY
INN
11826
Created by admin on Wed Apr 02 10:41:03 GMT 2025 , Edited by admin on Wed Apr 02 10:41:03 GMT 2025
PRIMARY
SMS_ID
300000035100
Created by admin on Wed Apr 02 10:41:03 GMT 2025 , Edited by admin on Wed Apr 02 10:41:03 GMT 2025
PRIMARY
FDA UNII
2C6A9NH2Z8
Created by admin on Wed Apr 02 10:41:03 GMT 2025 , Edited by admin on Wed Apr 02 10:41:03 GMT 2025
PRIMARY
Related Record Type Details
ACTIVE MOIETY

Agent Modifications

Modification Process Modification Role Modification Type Amount Fragment Name Fragment ID
CD34+ Cell Labeling IMMUNOLOGICAL
LENTIVIRAL TRANSFECTION BETIBEGLOGENE DAROLENTIVEC 7VEJ4HT24J
CD34+ Enrichment CELL SEPARATION

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
VECTOR EXPRESSED PROTEIN UNSPECIFIED SUBSTANCE
f4353dfd
(not in database)
INSERTED GENE EXPRESSION VECTOR UNSPECIFIED SUBSTANCE
53ad4970
(not in database)
Name Property Type Amount Referenced Substance Defining Parameters References
ANTIGEN EXPRESSED BIOLOGICAL