Details
Stereochemistry | ACHIRAL |
Molecular Formula | C27H30O6 |
Molecular Weight | 450.5235 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)=CCOC1=CC=C(\C=C\C(=O)C2=CC=C(OCC=C(C)C)C=C2OCC(O)=O)C=C1
InChI
InChIKey=GFWRVVCDTLRWPK-KPKJPENVSA-N
InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+
Molecular Formula | C27H30O6 |
Molecular Weight | 450.5235 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including:
http://www.taisho.co.jp/en/company/release/2004/04_0803-e.htm
http://www.drugbank.ca/drugs/DB05197
Curator's Comment: Description was created based on several sources, including:
http://www.taisho.co.jp/en/company/release/2004/04_0803-e.htm
http://www.drugbank.ca/drugs/DB05197
Sofalcone is a mucosal protective agent that has been reported to inhibit growth of Helicobacter pylori. It is considered safe and effective for the treatment of gastritis and gastric ulcer. It is used in Japan. Adverse reactions are: liver dysfunction, jaundice, rash, constipation, dry mouth, heartburn.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: WP98 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | Solon Approved UseIt is used for the treatment of gastritis. Launch Date1984 |
|||
Primary | Solon Approved UseIt is used as peptic ulcer agent. Launch Date1984 |
PubMed
Title | Date | PubMed |
---|---|---|
Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. | 1994 Dec |
|
Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection. | 1998 |
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Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin. | 2005 Mar 21 |
Patents
Sample Use Guides
In Vivo Use Guide
Curator's Comment: The dosage may be adjusted in accordance with age and symptoms.
Adults take 100 mg of sofalcone 3 times a day.
Route of Administration:
Oral
In Vitro Use Guide
Sources: http://medical.taishotoyama.co.jp/data/if/pdf/sl.pdf
MIC50 for Helicobacter pylori is 12.5 ug/ml
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:52:01 GMT 2023
by
admin
on
Fri Dec 15 15:52:01 GMT 2023
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Record UNII |
2B668TJX8E
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Record Status |
Validated (UNII)
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Record Version |
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-
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C1745
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153175-87-2
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100000084062
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CHEMBL1441961
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5321
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m10098
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SUB10574MIG
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2456
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135732
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DB05197
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64506-49-6
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NON-SPECIFIC STEREOCHEMISTRY | |||
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C81118
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C035032
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SOFALCONE
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2B668TJX8E
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Related Record | Type | Details | ||
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ACTIVE MOIETY |