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Details

Stereochemistry ACHIRAL
Molecular Formula C27H30O6
Molecular Weight 450.5235
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of SOFALCONE

SMILES

CC(C)=CCOC1=CC=C(\C=C\C(=O)C2=CC=C(OCC=C(C)C)C=C2OCC(O)=O)C=C1

InChI

InChIKey=GFWRVVCDTLRWPK-KPKJPENVSA-N
InChI=1S/C27H30O6/c1-19(2)13-15-31-22-8-5-21(6-9-22)7-12-25(28)24-11-10-23(32-16-14-20(3)4)17-26(24)33-18-27(29)30/h5-14,17H,15-16,18H2,1-4H3,(H,29,30)/b12-7+

HIDE SMILES / InChI

Molecular Formula C27H30O6
Molecular Weight 450.5235
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including: http://www.taisho.co.jp/en/company/release/2004/04_0803-e.htm http://www.drugbank.ca/drugs/DB05197

Sofalcone is a mucosal protective agent that has been reported to inhibit growth of Helicobacter pylori. It is considered safe and effective for the treatment of gastritis and gastric ulcer. It is used in Japan. Adverse reactions are: liver dysfunction, jaundice, rash, constipation, dry mouth, heartburn.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Solon

Approved Use

It is used for the treatment of gastritis.

Launch Date

1984
Primary
Solon

Approved Use

It is used as peptic ulcer agent.

Launch Date

1984
PubMed

PubMed

TitleDatePubMed
Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori.
1994 Dec
Preliminary study on a novel quadruple eradication therapy with a mucoprotective drug, sofalcone, for Helicobacter pylori infection.
1998
Sofalcone, a mucoprotective agent, increases the cure rate of Helicobacter pylori infection when combined with rabeprazole, amoxicillin and clarithromycin.
2005 Mar 21
Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment: The dosage may be adjusted in accordance with age and symptoms.
Adults take 100 mg of sofalcone 3 times a day.
Route of Administration: Oral
MIC50 for Helicobacter pylori is 12.5 ug/ml
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:52:01 GMT 2023
Edited
by admin
on Fri Dec 15 15:52:01 GMT 2023
Record UNII
2B668TJX8E
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SOFALCONE
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
SOFALCONE [MI]
Common Name English
SOLON
Brand Name English
SOFALCONE [JAN]
Common Name English
(5-((3-METHYL-2-BUTENYL)OXY)-2-(P-((3-METHYL-2-BUTENYL)OXY)CINNAMOYL)PHENOXY)ACETIC ACID
Systematic Name English
sofalcone [INN]
Common Name English
ACETIC ACID, 2-(5-((3-METHYL-2-BUTEN-1-YL)OXY)-2-((2E)-3-(4-((3-METHYL-2-BUTEN-1-YL)OXY)PHENYL)-1-OXO-2-PROPEN-1-YL)PHENOXY)-
Systematic Name English
SU-88
Code English
Sofalcone [WHO-DD]
Common Name English
SOFALCONE [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1745
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
Code System Code Type Description
CAS
153175-87-2
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
SMS_ID
100000084062
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
ChEMBL
CHEMBL1441961
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
INN
5321
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
MERCK INDEX
m10098
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY Merck Index
EVMPD
SUB10574MIG
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
DRUG CENTRAL
2456
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
PUBCHEM
5282219
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
CHEBI
135732
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
DRUG BANK
DB05197
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
CAS
64506-49-6
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
NON-SPECIFIC STEREOCHEMISTRY
NCI_THESAURUS
C81118
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
MESH
C035032
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
WIKIPEDIA
SOFALCONE
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
FDA UNII
2B668TJX8E
Created by admin on Fri Dec 15 15:52:01 GMT 2023 , Edited by admin on Fri Dec 15 15:52:01 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY