U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula I.Na
Molecular Weight 145.8954
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM IODIDE I-123

SMILES

[Na+].[123I-]

InChI

InChIKey=FVAUCKIRQBBSSJ-VVUPZWBASA-M
InChI=1S/HI.Na/h1H;/q;+1/p-1/i1-4;

HIDE SMILES / InChI
Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula HI
Molecular Weight 123.9135
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Iodide ion I-123 is the most suitable isotope of iodine for the diagnostic study of thyroid diseases. Sodium Iodide I 131 Capsules Diagnostic is indicated for use in adults for: Assessment of thyroid function using radioactive iodine (RAI) uptake test and Imaging the thyroid (scintigraphy). The following adverse reaction has been described elsewhere in the labeling: Hypersensitivity Reactions. The following adverse reactions have been identified during post-approval use from Sodium Iodide I 131 Capsules Diagnostic: Gastrointestinal disorders (vomiting, nausea, and diarrhea); General disorders and administration site conditions (local thyroid swelling); Immune system disorders (hypersensitivity reactions); Skin and subcutaneous tissue disorders (itching, rash, hives, and erythema). Certain drugs and iodine-containing foods interfere with the accumulation of radioiodide by the thyroid.

Approval Year

1976
91
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
SODIUM IODIDE I 123

Approved Use

Unknown

Launch Date

1976

Sample Use Guides

In Vivo Use Guide
The recommended oral dose range for diagnostic studies of thyroid function in the average adult patient (70 kg) is 3.7-14.8 MBq (100-400 uCi) of Sodium Iodide I-123. The lower portion of the range 3.7 MBq (100 uCi) is recommended for uptake studies alone, and the higher portion 14.8 MBq (400 uCi) for thyroid imaging.
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:06 GMT 2023
Edited
by admin
on Fri Dec 15 15:46:06 GMT 2023
Record UNII
29UKX3A616
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SODIUM IODIDE I-123
ORANGE BOOK  
Common Name English
SODIUM IODIDE, I-123
Common Name English
SODIUM IODIDE (123I)
Common Name English
SODIUM IODIDE I-123 [ORANGE BOOK]
Common Name English
SODIUM IODIDE (123 I)
WHO-DD  
Common Name English
SODIUM IODIDE I123
Common Name English
SODIUM IODIDE I 123 [USP IMPURITY]
Common Name English
SODIUM IODIDE-123
Common Name English
SODIUM IODIDE,I-123 [VANDF]
Common Name English
SODIUM IODIDE I 123
USP  
Common Name English
Sodium iodide (123 i) [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QV09FX02
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
NDF-RT N0000177914
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
NCI_THESAURUS C2125
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
WHO-ATC V09FX02
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
Code System Code Type Description
FDA UNII
29UKX3A616
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
ChEMBL
CHEMBL1644695
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
CAS
41927-88-2
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
PUBCHEM
11954386
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
DAILYMED
29UKX3A616
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
LACTMED
Sodium Iodide I 123
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
EVMPD
SUB12291MIG
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
ALTERNATIVE
RXCUI
91531
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY RxNorm
EVMPD
SUB15296MIG
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
EPA CompTox
DTXSID40984138
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
DRUG BANK
DBSALT002459
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
SMS_ID
100000078113
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
NCI_THESAURUS
C47724
Created by admin on Fri Dec 15 15:46:06 GMT 2023 , Edited by admin on Fri Dec 15 15:46:06 GMT 2023
PRIMARY
Related Record Type Details
Structure of IODIDE ION I-123
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966