QUINUPRAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H24N2
Molecular Weight	304.4287
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CN2CCC1C(C2)N3C4=C(CCC5=C3C=CC=C5)C=CC=C4

InChI

InChIKey=JCBQCKFFSPGEDY-UHFFFAOYSA-N

InChI=1S/C21H24N2/c1-3-7-19-16(5-1)9-10-17-6-2-4-8-20(17)23(19)21-15-22-13-11-18(21)12-14-22/h1-8,18,21H,9-15H2

HIDE SMILES / InChI

Molecular Formula	C21H24N2
Molecular Weight	304.4287
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16644151 | https://www.ncbi.nlm.nih.gov/pubmed/2613103 | (1984) The Japanese Journal of Pharmacology, page 458, retrieved from: https://books.google.ru/books?id=1UfYAAAAIAAJ

Quinupramine is a tricyclic antidepressant used in the treatment of reactive and endogenous depression. Quinupramine was found to possess a higher affinity for muscarinic cholinergic receptor binding sites in brain and heart, compared with imipramine. Quinupramine also displayed a substantial affinity for 5-HT2 receptors in the cerebral cortex. Quinupramine may show many adverse side effects such as dry mouth, urinary retention, and daytime drowsiness.

Approval Year

PubMed

Title	Date	PubMed
[Behavioral effects of quinupramine, a new tricyclic antidepressant].	1988 Jun	3417209
Rapid high-performance liquid chromatographic measurement of buspirone in human plasma after overdose.	2004 Nov	15386505
Physicochemical characteristics of quinupramine in the EVA matrix.	2006 Aug 31	16844330
Enhanced transdermal controlled delivery of glimepiride from the ethylene-vinyl acetate matrix.	2009 Aug	19606946
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443

Sample Use Guides

In Vivo Use Guide

5–15 mg daily dose

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:38:17 GMT 2023` Edited by `admin` on `Fri Dec 15 17:38:17 GMT 2023`
Record UNII	29O61HFF4L
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

QUINUPRAMINE

Official Name

English

QUINUPRAMINE [MART.]

Common Name

English

Quinupramine [WHO-DD]

Common Name

English

quinupramine [INN]

Common Name

English

10,11-DIHYDRO-5-(3-QUINUCLIDINYL)-5H-DIBENZ(B,F)AZEPINE

Systematic Name

English

QUINUPRAMINE [MI]

Common Name

English

Classification Tree Code System Code

WHO-ATC

N06AA23