PIRENOXINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H8N2O5
Molecular Weight	308.2451
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)C1=NC2=C(C(O)=C1)C3=NC4=CC=CC=C4OC3=CC2=O

InChI

InChIKey=OKPNYGAWTYOBFZ-UHFFFAOYSA-N

InChI=1S/C16H8N2O5/c19-9-5-8(16(21)22)18-14-10(20)6-12-15(13(9)14)17-7-3-1-2-4-11(7)23-12/h1-6H,(H,18,19)(H,21,22)

HIDE SMILES / InChI

Molecular Formula	C16H8N2O5
Molecular Weight	308.2451
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.ncbi.nlm.nih.gov/pubmed/21850160
Curator's Comment: description was created based on several sources, including, http://www.fda.gov.tw/MLMS/ShowFile.aspx?LicId=02021053&Seq=007&Type=9

Pirenoxine is an anti-cataract agent which is used in many asian countries under the name Catalin. Although its efficacy is not proved scientifically, the drug may play an important role in cataract prevention. It is supposed that the anti-cataract effect of pirenoxine results from inhibition of sulfhydryl combination of quinoid substances with lens proteins and the inhibition leads to the maintenance of lens transparency.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
maintenance of lens transparency 2 Target ID: GO:0036438 Sources: http://www.ncbi.nlm.nih.gov/pubmed/21850160	Activator 1430

Conditions

Condition	Modality	Targets	Highest Phase	Product
Senile cataract 2 Sources: http://www.fda.gov.tw/MLMS/ShowFile.aspx?LicId=02021053&Seq=007&Type=9	Preventing		Approved 8429	CATALIN Approved Use Early stage of senile cataract.

PubMed

Title	Date	PubMed
Antioxidant protection in cultured corneal cells and whole corneas submitted to UV-B exposure.	2003 Oct 15	14705640
[Evaluation of effectiveness of Catalin eyedrops in patients with presenile and senile cataract].	2004	15787181
Contact dermatitis due to pirfenoxone.	2004 Jun	15274732
Pirenoxine prevents oxidative effects of argon fluoride excimer laser irradiation in rabbit corneas: biochemical, histological and cytofluorimetric evaluations.	2005 Jan 14	15629247
Why are physicians not persuaded by scientific evidence? A grounded theory interview study.	2006 Jul 27	16872522
[Efficacy of catalin eyed drops in age-related cataract agents].	2010 Jan-Feb	20645574

Patents

Sample Use Guides

In Vivo Use Guide

Dissolve the granules (0.75 mg) in 15 ml of the vehicle just before use and instill 1-2 drops of the solution, 3-5 times a day

Route of Administration: Other

In Vitro Use Guide

Pirenoxine (1,000 uM) decreased UVC-induced turbidity formation compared to controls after 4 h of UVC exposure. The absolute gamma-crystallin turbidity induced by 4 h of UVC exposure was ameliorated in the presence of catalin equivalent to 1-100 uM of the drug in a concentration-dependent manner. Pirenoxine at 0.03, 0.1, and 0.3 uM significantly delayed 10 mM selenite- and calcium-induced turbidity formation compared to controls on days 0-4.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:29:13 GMT 2023` Edited by `admin` on `Fri Dec 15 16:29:13 GMT 2023`
Record UNII	27L0EP6IZK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIRENOXINE

Official Name

English

pirenoxine [INN]

Common Name

English

PIRENOXINE [JAN]

Common Name

English

PIRENOXINE [MI]

Common Name

English

CATALIN-K

Brand Name

English

Pirenoxine [WHO-DD]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QS01XA91