U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Dirucotide (MBP 8298) is a synthetic myelin basic protein (MBP) peptide designed to decrease type 2 helper T cells (TH2)-mediated B-cell signalling of auto-reactive T-cells thereby reducing the production of specific antibodies that target endogenous MBP. MBP is the dominant site of attack in patients with multiple sclerosis and haplotype (HLA) DR2 or DR4. Dirucotide did not meet the primary endpoint of delaying disease progression, as measured by the Expanded Disability Status Scale (EDSS), during the two-year MAESTRO-01 Phase III trial in patients with secondary progressive multiple sclerosis (SPMS). In addition, there were no statistically significant differences between dirucotide and placebo on the secondary endpoints of the study. After disappointing trial results, development of the drug was ended in 2009.

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 08:04:23 UTC 2023
Edited
by admin
on Thu Jul 06 08:04:23 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
26188K0CWH
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIRUCOTIDE
INN   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
DIRUCOTIDE [MI]
Common Name English
MBP8298
Code English
dirucotide [INN]
Common Name English
MBP-8298
Code English
Dirucotide [WHO-DD]
Common Name English
L-THREONINE, L-.ALPHA.-ASPARTYL-L-.ALPHA.-GLUTAMYL-L-ASPARAGINYL-L-PROLYL-L-VALYL-L-VALYL-L-HISTIDYL-L-PHENYLALANYL-L-PHENYLALANYL-L-LYSYL-L-ASPARAGINYL-L-ISOLEUCYL-L-VALYL-L-THREONYL-L-PROLYL-L-ARGINYL-
Common Name English
H2N-ASP-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR-OH
Common Name English
ASP-GLU-ASN-PRO-VAL-VAL-HIS-PHE-PHE-LYS-ASN-ILE-VAL-THR-PRO-ARG-THR
Common Name English
DIRUCOTIDE [USAN]
Common Name English
Code System Code Type Description
CAS
152074-97-0
Created by admin on Thu Jul 06 08:04:23 UTC 2023 , Edited by admin on Thu Jul 06 08:04:23 UTC 2023
PRIMARY
USAN
TT-106
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
MERCK INDEX
M4666
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY Merck Index
FDA UNII
26188K0CWH
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
WIKIPEDIA
DIRUCOTIDE
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
INN
9014
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
DRUG BANK
DB04921
Created by admin on Thu Jul 06 08:04:23 UTC 2023 , Edited by admin on Thu Jul 06 08:04:23 UTC 2023
PRIMARY
EPA CompTox
DTXSID101336603
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
EVMPD
SUB79317
Created by admin on Thu Jul 06 08:04:23 UTC 2023 , Edited by admin on Thu Jul 06 08:04:23 UTC 2023
PRIMARY
PUBCHEM
44151255
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
ChEMBL
CHEMBL2105639
Created by admin on Thu Jul 06 08:04:23 UTC 2023 , Edited by admin on Thu Jul 06 08:04:23 UTC 2023
PRIMARY
NCI_THESAURUS
C166542
Created by admin on Thu Jul 06 08:04:24 UTC 2023 , Edited by admin on Thu Jul 06 08:04:24 UTC 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL