Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C28H28I6N4O10S.C7H17NO5 |
Molecular Weight | 1569.248 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCN(C(C)=O)C1=C(I)C(NC(=O)CCS(=O)(=O)CCC(=O)NC2=C(I)C(C(O)=O)=C(I)C(N(CC)C(C)=O)=C2I)=C(I)C(C(O)=O)=C1I
InChI
InChIKey=IRYYCWRQWAKJMU-WZTVWXICSA-N
InChI=1S/C28H28I6N4O10S.C7H17NO5/c1-5-37(11(3)39)25-19(31)15(27(43)44)17(29)23(21(25)33)35-13(41)7-9-49(47,48)10-8-14(42)36-24-18(30)16(28(45)46)20(32)26(22(24)34)38(6-2)12(4)40;1-8-2-4(10)6(12)7(13)5(11)3-9/h5-10H2,1-4H3,(H,35,41)(H,36,42)(H,43,44)(H,45,46);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
Molecular Formula | C7H17NO5 |
Molecular Weight | 195.2136 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 4 / 4 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Molecular Formula | C28H28I6N4O10S |
Molecular Weight | 1374.035 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Iosulamide is triiodobenzoic acid derivative patented by Sterling Drug Inc as an X-ray contrast agent. Iosulamide shows clear advantages in animal tests over meglumine iodipamide. The intravenous toxicity of Iosulamide meglumine is considerably lower than that of iodipamide (Cholografin) in the mouse and rat. Studies of biliary and urinary excretion patterns indicate Iosulamide is rapidly excreted compared to iodipamide, while at the same time providing equal concentrations in bile. More efficient blood to bile clearance rate and a shorter blood half-life for Iosulamide may account for the lower circulating blood levels and rapid total excretion compared to iodipamide. Iosulamide's rapid blood-bile clearance coupled with its extremely low toxicity may allow rapid administration of high doses, affording superior visualization and safety compared to iodipamide.
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:14:36 GMT 2023
by
admin
on
Fri Dec 15 19:14:36 GMT 2023
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Record UNII |
255T933X5M
|
Record Status |
Validated (UNII)
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Record Version |
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-
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Common Name | English |
Code System | Code | Type | Description | ||
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CHEMBL1615440
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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PRIMARY | |||
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C028779
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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C166540
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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PRIMARY | |||
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63534-64-5
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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PRIMARY | |||
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15942842
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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PRIMARY | |||
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255T933X5M
Created by
admin on Fri Dec 15 19:14:36 GMT 2023 , Edited by admin on Fri Dec 15 19:14:36 GMT 2023
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PRIMARY |
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PARENT -> SALT/SOLVATE | |||
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Related Record | Type | Details | ||
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ACTIVE MOIETY |