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Details

Stereochemistry ACHIRAL
Molecular Formula C32H16N8.Zn
Molecular Weight 577.932
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CIAFTALAN ZINC

SMILES

[Zn++].[N-]1C2=NC3=NC(=NC4=C5C=CC=CC5=C([N-]4)N=C6N=C(N=C1C7=C2C=CC=C7)C8=C6C=CC=C8)C9=C3C=CC=C9

InChI

InChIKey=PODBBOVVOGJETB-UHFFFAOYSA-N
InChI=1S/C32H16N8.Zn/c1-2-10-18-17(9-1)25-33-26(18)38-28-21-13-5-6-14-22(21)30(35-28)40-32-24-16-8-7-15-23(24)31(36-32)39-29-20-12-4-3-11-19(20)27(34-29)37-25;/h1-16H;/q-2;+2

HIDE SMILES / InChI

Molecular Formula Zn
Molecular Weight 65.409
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C32H18N8
Molecular Weight 514.5389
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Ciaftalan Zinc (also known as Zinc(II)-phthalocyanine) is phthalocyanine and photosensitizers which showed a high activity in photodynamic therapy studies on a variety of animal tumors. Ciaftalan Zinc belongs to second generation photosensitizers that have a more intense long wavelength absorption and greater extinction coefficient compare to the first generation. The greater the extinction coefficient value associated with greater efficacy, smaller drug dosage required to induce a cytotoxic response and diminished risk of provoking systemic toxic reactions. The long absorption wavelength correlates with higher penetration depth and it is, therefore, Ciaftalan Zinc causes deep tumor necrosis in animal models. Currently, Tetra-triethyleneoxysulfonyl substituted Ciaftalan Zinc derivatives are studied as novel photodynamic therapy of cancer.

Originator

Curator's Comment: Journal of Chemical Physics (1953), 21, 73-80.

Approval Year

PubMed

PubMed

TitleDatePubMed
Tetra-triethyleneoxysulfonyl substituted zinc phthalocyanine for photodynamic cancer therapy.
2016 Mar
Patents

Patents

Substance Class Chemical
Created
by admin
on Wed Jul 05 23:41:29 UTC 2023
Edited
by admin
on Wed Jul 05 23:41:29 UTC 2023
Record UNII
243KJ527MC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CIAFTALAN ZINC
INN  
INN  
Official Name English
(SP-4-1)-(PHTHALOCYANINATO(2-)-N(SUP 29),N(SUP 30),N(SUP 31),N(SUP 32))ZINC
Common Name English
ciaftalan zinc [INN]
Common Name English
(SP-4-1)-(PHTHALOCYANINATO(2-)-N29,N30,N31,N32)ZINC
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C798
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
NCI_THESAURUS C1420
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
Code System Code Type Description
SMS_ID
100000081879
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
PUBCHEM
114933
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
EVMPD
SUB06223MIG
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
FDA UNII
243KJ527MC
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
CHEBI
51218
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
ECHA (EC/EINECS)
238-262-5
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
CAS
14320-04-8
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
EPA CompTox
DTXSID90931773
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
INN
7391
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
NCI_THESAURUS
C79758
Created by admin on Wed Jul 05 23:41:29 UTC 2023 , Edited by admin on Wed Jul 05 23:41:29 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE