BENZARONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H14O3
Molecular Weight	266.2913
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of BENZARONE

Structure Search

SMILES

CCC1=C(C(=O)C2=CC=C(O)C=C2)C3=C(O1)C=CC=C3

InChI

InChIKey=RFRXIWQYSOIBDI-UHFFFAOYSA-N

InChI=1S/C17H14O3/c1-2-14-16(13-5-3-4-6-15(13)20-14)17(19)11-7-9-12(18)10-8-11/h3-10,18H,2H2,1H3

HIDE SMILES / InChI

Molecular Formula	C17H14O3
Molecular Weight	266.2913
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15799034 | https://www.ncbi.nlm.nih.gov/pubmed/21449597

Benzarone is a human uric acid transporter 1 inhibitor and causes hepatotoxicity.

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Solute carrier family 22 member 12 10 Target ID: CHEMBL6120 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21449597	Inhibitor 8297		0.12 µM [IC50]

PubMed

PubMed

Title	Date	PubMed
Subfulminant hepatitis requiring liver transplantation after benzarone administration.	1994 Jun	7930488

Patents

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:05:17 GMT 2023` Edited by `admin` on `Fri Dec 15 15:05:17 GMT 2023`
Record UNII	23ZW4BG89C
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZARONE

Official Name

English

L-2197

Code

English

BENZARONE [MART.]

Common Name

English

benzarone [INN]

Common Name

English

L 2197

Code

English

NSC-82134

Code

English

Benzarone [WHO-DD]

Common Name

English

BENZARONE [MI]

Common Name

English

2-ETHYL-3-BENZOFURANYL P-HYDROXYPHENYL KETONE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29750

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

Code System Code Type Description

FDA UNII

23ZW4BG89C

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

PRIMARY

MERCK INDEX

m580

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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Merck Index

ECHA (EC/EINECS)

216-026-2

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

PRIMARY

ChEMBL

CHEMBL1474963

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

PRIMARY

PUBCHEM

255968

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

PRIMARY

INN

1426

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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RXCUI

18923

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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RxNorm

EVMPD

SUB05740MIG

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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NCI_THESAURUS

C74411

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

PRIMARY

MESH

C004528

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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DRUG CENTRAL

317

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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EPA CompTox

DTXSID2061721

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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NSC

82134

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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CAS

1477-19-6

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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SMS_ID

100000086361

Created by admin on Fri Dec 15 15:05:17 GMT 2023 , Edited by admin on Fri Dec 15 15:05:17 GMT 2023

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Related Record Type Details


					23ZW4BG89C

BENZARONE

ACTIVE MOIETY