Iluzanebart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:44:00 GMT 2025` Edited by `admin` on `Wed Apr 02 12:44:00 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Type	COMPLETE
Record UNII	23Q5AU2MD5
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Iluzanebart

Official Name

English

VGL-101

Preferred Name

English

ILUZANEBART [USAN]

Common Name

English

gamma1 heavy chain Homo sapiens (1-451) [VH (Homo sapiens IGHV5-51*01 (96.9%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, G1v54-30 CH2 C83, G84.4, C85 (CH1 R

Common Name

English

Immunoglobulin G1 [296-cysteine,301-glycine,306-cysteine], anti-(human triggering receptor expressed on myeloid cells 2) (human monoclonal VGL101 ?1-chain), disulfide with human monoclonal VGL101 ?-chain, dimer

Common Name

English

iluzanebart [INN]

Common Name

English

VGL101

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

831521

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

Code System Code Type Description

INN

12479

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

FDA UNII

23Q5AU2MD5

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

NCI_THESAURUS

C199007

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

USAN

MN-119

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

SMS_ID

300000049200

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

CAS

2733621-19-5

Created by admin on Wed Apr 02 12:44:00 GMT 2025 , Edited by admin on Wed Apr 02 12:44:00 GMT 2025

PRIMARY

From	To
4_194	4_214
4_88	4_134
1_22	1_96
1_371	1_429
2_22	2_96
2_148	4_23
2_230	2_233
1_148	1_204
2_265	2_296
2_306	2_325
2_371	2_429
3_88	3_134
3_194	3_214
1_224	3_23
1_230	2_204
1_233	2_224
1_265	1_296
1_306	1_325

Related Record Type Details


					A72IN5R4OC

TREM2

TARGET -> AGONIST

Amount:

Related Record Type Details


					23Q5AU2MD5

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS	K		LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL