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Details

Stereochemistry ACHIRAL
Molecular Formula C21H23N7O3S
Molecular Weight 453.517
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GSK-1268997

SMILES

CN(C1=CC2=NN(C)C(C)=C2C=C1)C3=CC=NC(NC4=CC=C(CO)C(=C4)S(N)(=O)=O)=N3

InChI

InChIKey=FHOXOPMJIMHUOC-UHFFFAOYSA-N
InChI=1S/C21H23N7O3S/c1-13-17-7-6-16(11-18(17)26-28(13)3)27(2)20-8-9-23-21(25-20)24-15-5-4-14(12-29)19(10-15)32(22,30)31/h4-11,29H,12H2,1-3H3,(H2,22,30,31)(H,23,24,25)

HIDE SMILES / InChI

Molecular Formula C21H23N7O3S
Molecular Weight 453.517
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 07:56:18 UTC 2023
Edited
by admin
on Sat Dec 16 07:56:18 UTC 2023
Record UNII
23M9H61WO8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GSK-1268997
Common Name English
5-((4-((2,3-DIMETHYLINDAZOL-6-YL)-METHYL-AMINO)PYRIMIDIN-2-YL)AMINO)-2-(HYDROXYMETHYL)BENZENESULFONAMIDE
Systematic Name English
GSK1268997
Code English
PAZOPANIB METABOLITE M26
Common Name English
Code System Code Type Description
CAS
1414375-50-0
Created by admin on Sat Dec 16 07:56:18 UTC 2023 , Edited by admin on Sat Dec 16 07:56:18 UTC 2023
PRIMARY
PUBCHEM
72942038
Created by admin on Sat Dec 16 07:56:18 UTC 2023 , Edited by admin on Sat Dec 16 07:56:18 UTC 2023
PRIMARY
FDA UNII
23M9H61WO8
Created by admin on Sat Dec 16 07:56:18 UTC 2023 , Edited by admin on Sat Dec 16 07:56:18 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> METABOLITE ACTIVE
Only one of these metabolites (GSK1268997) has been shown to inhibit the proliferation of VEGF-stimulated human umbilical vein endothelial cells with potency similar to pazopanib. The other metabolites show at least 10- to 20-fold less activity than the parent compound in the same cellular assay.