GSK-1268997

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H23N7O3S
Molecular Weight	453.517
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C1=CC2=NN(C)C(C)=C2C=C1)C3=CC=NC(NC4=CC=C(CO)C(=C4)S(N)(=O)=O)=N3

InChI

InChIKey=FHOXOPMJIMHUOC-UHFFFAOYSA-N

InChI=1S/C21H23N7O3S/c1-13-17-7-6-16(11-18(17)26-28(13)3)27(2)20-8-9-23-21(25-20)24-15-5-4-14(12-29)19(10-15)32(22,30)31/h4-11,29H,12H2,1-3H3,(H2,22,30,31)(H,23,24,25)

HIDE SMILES / InChI

Molecular Formula	C21H23N7O3S
Molecular Weight	453.517
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 07:56:18 GMT 2023` Edited by `admin` on `Sat Dec 16 07:56:18 GMT 2023`
Record UNII	23M9H61WO8
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GSK-1268997

Common Name

English

5-((4-((2,3-DIMETHYLINDAZOL-6-YL)-METHYL-AMINO)PYRIMIDIN-2-YL)AMINO)-2-(HYDROXYMETHYL)BENZENESULFONAMIDE

Systematic Name

English

GSK1268997

Code

English

PAZOPANIB METABOLITE M26

Common Name

English

Code System Code Type Description

CAS

1414375-50-0

Created by admin on Sat Dec 16 07:56:18 GMT 2023 , Edited by admin on Sat Dec 16 07:56:18 GMT 2023

PRIMARY

PUBCHEM

72942038

Created by admin on Sat Dec 16 07:56:18 GMT 2023 , Edited by admin on Sat Dec 16 07:56:18 GMT 2023

PRIMARY

FDA UNII

23M9H61WO8

Created by admin on Sat Dec 16 07:56:18 GMT 2023 , Edited by admin on Sat Dec 16 07:56:18 GMT 2023

PRIMARY

Related Record Type Details


					7RN5DR86CK

PAZOPANIB

PARENT -> METABOLITE ACTIVE

Comments:

Only one of these metabolites (GSK1268997) has been shown to inhibit the proliferation of VEGF-stimulated human umbilical vein endothelial cells with potency similar to pazopanib. The other metabolites show at least 10- to 20-fold less activity than the parent compound in the same cellular assay.