U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C14H30O2S2
Molecular Weight 294.517
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIADENOL

SMILES

OCCSCCCCCCCCCCSCCO

InChI

InChIKey=WRCITXQNXAIKLR-UHFFFAOYSA-N
InChI=1S/C14H30O2S2/c15-9-13-17-11-7-5-3-1-2-4-6-8-12-18-14-10-16/h15-16H,1-14H2

HIDE SMILES / InChI
Molecular Formula C14H30O2S2
Molecular Weight 294.517
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tiadenol (2,2'-(decamethylenedithio)-diethanol) exrets hepatic peroxisome proliferative activity, it induces peroxisomal enzymes and peroxisome proliferation. Tiadenol is known for its hypolipidemic properties.

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Peroxisome proliferators attenuate free arachidonic acid pool in the kidney through inducing lysophospholipid acyltransferases.
2009-10
Morphological transformation and catalase activity of Syrian hamster embryo cells treated with hepatic peroxisome proliferators, TPA and nickel sulphate.
1990-01
Peroxisome proliferation in primary cultures of rat hepatocytes.
1983-01
[Tolerability and side-effects of bis-(hydroxy-2-ethylthio)-1,10-decane (BS 530) as compared with clofibrate in the therapy of hyperlipemia].
1979-10-31

Sample Use Guides

In Vitro Use Guide
The enhancement of palmitoyl-CoA hydrolase, carnitine acetyl-transferase and catalase activities in cultured C3H/10T1/2 cells was dose-related over a concentration range of 2 to 20 microM tiadenol, depending on the enzyme assayed.
Substance Class Chemical
Created
by admin
on Wed Apr 02 09:33:26 GMT 2025
Edited
by admin
on Wed Apr 02 09:33:26 GMT 2025
Record UNII
22251270CX
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TIADENOL
INN   MART.   MI   WHO-DD  
INN  
Official Name English
DELIPID
Preferred Name English
EULIP
Brand Name English
TIADENOL [MART.]
Common Name English
ETHANOL, 2,2'-(1,10-DECANEDIYLBIS(THIO))BIS-
Systematic Name English
1,10-BIS(2-HYDROXYETHYLTHIO)DECANE
Systematic Name English
LL-1558
Code English
TIATEROL
Common Name English
Tiadenol [WHO-DD]
Common Name English
ETHANOL, 2,2'-(DECAMETHYLENEDITHIO)DI-
Systematic Name English
TIADENOL [MI]
Common Name English
THIADENOL
Common Name English
1,10-BIS(HYDROXYETHYLTHIO)DECANE
Systematic Name English
FONLIPOL
Brand Name English
2,2'-(DECAMETHYLENEDITHIO)DIETHANOL
Systematic Name English
NSC-66316
Code English
tiadenol [INN]
Common Name English
FINLIPOL
Brand Name English
1,10-BIS(.BETA.-HYDROXYETHYLTHIO)DECANE
Systematic Name English
LL 1558
Code English
3,14-DITHIA-1,16-HEXADECANEDIOL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C29703
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
WHO-VATC QC10AX03
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
WHO-ATC C10AX03
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
Code System Code Type Description
ChEMBL
CHEMBL1697775
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
EVMPD
SUB10998MIG
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
EPA CompTox
DTXSID50219903
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
NSC
66316
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
CAS
6964-20-1
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
WIKIPEDIA
TIADENOL
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
ECHA (EC/EINECS)
230-165-6
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
PUBCHEM
23403
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
DRUG BANK
DB13348
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
NCI_THESAURUS
C152597
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
FDA UNII
22251270CX
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
MESH
C004568
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
MERCK INDEX
m10841
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY Merck Index
RXCUI
38248
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY RxNorm
DRUG CENTRAL
2647
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
SMS_ID
100000082154
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
INN
3253
Created by admin on Wed Apr 02 09:33:26 GMT 2025 , Edited by admin on Wed Apr 02 09:33:26 GMT 2025
PRIMARY
Related Record Type Details
Structure of TIADENOL
ACTIVE MOIETY
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966