SUFOSFAMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C8H18ClN2O5PS
Molecular Weight	320.731
Optical Activity	( + / - )
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CS(=O)(=O)OCCNP1(=O)OCCCN1CCCl

InChI

InChIKey=ZSZKJARKHWCBJK-UHFFFAOYSA-N

InChI=1S/C8H18ClN2O5PS/c1-18(13,14)16-8-4-10-17(12)11(6-3-9)5-2-7-15-17/h2-8H2,1H3,(H,10,12)

HIDE SMILES / InChI

Molecular Formula	C8H18ClN2O5PS
Molecular Weight	320.731
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6627244 | https://www.ncbi.nlm.nih.gov/pubmed/3581517 | https://www.ncbi.nlm.nih.gov/pubmed/114192

Sufosfamide is an oxazaphosphorine derivative patented by Asta-Werke A.-G as immunosuppressives agent. Sufosfamide is a mixed-function oxazaphosphorine differing from ifosfamide in that the extracyclic 2-chloroethyl function has been replaced by a mesyl-oxyethyl group. It is characterized by an extraordinary intensifi¬cation of the immunosuppressive component of action compared to the carcinotoxic component. Sufosfamide activates of a specific immune tolerance in models of humoral end cell-bound antibodies.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

rat 10-15 mg/kg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:40:33 GMT 2023` Edited by `admin` on `Sat Dec 16 17:40:33 GMT 2023`
Record UNII	2208Y59985
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SUFOSFAMIDE

Official Name

English

sufosfamide [INN]

Common Name

English

ETHANOL, 2-((3-(2-CHLOROETHYL)TETRAHYDRO-2-OXIDO-2H-1,3,2-OXAZAPHOSPHORIN-2-YL)AMINO)-, 1-METHANESULFONATE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710