Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C8H18ClN2O5PS |
| Molecular Weight | 320.731 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CS(=O)(=O)OCCNP1(=O)OCCCN1CCCl
InChI
InChIKey=ZSZKJARKHWCBJK-UHFFFAOYSA-N
InChI=1S/C8H18ClN2O5PS/c1-18(13,14)16-8-4-10-17(12)11(6-3-9)5-2-7-15-17/h2-8H2,1H3,(H,10,12)
| Molecular Formula | C8H18ClN2O5PS |
| Molecular Weight | 320.731 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sufosfamide is an oxazaphosphorine derivative patented by Asta-Werke A.-G as immunosuppressives agent. Sufosfamide is a mixed-function oxazaphosphorine differing from ifosfamide in that the extracyclic 2-chloroethyl function has been replaced by a mesyl-oxyethyl group. It is characterized by an extraordinary intensifi¬cation of the immunosuppressive component of action compared to the carcinotoxic component. Sufosfamide activates of a specific immune tolerance in models of humoral end cell-bound antibodies.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Studies on the urotoxicity of oxazaphosphorine cytostatics and its prevention--I. Experimental studies on the urotoxicity of alkylating compounds. | 1981-06 |
|
| [Immunosuppression and induction of tolerance by 3-(2-chloroethyl)-2(2-mesyloxyethylamino)-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide (ASTA 5122)]. | 1974-08 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 09:25:16 GMT 2025
by
admin
on
Wed Apr 02 09:25:16 GMT 2025
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| Record UNII |
2208Y59985
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| Record Status |
Validated (UNII)
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| Record Version |
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Official Name | English | ||
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Preferred Name | English | ||
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C29710
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CHEMBL471721
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C73260
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2208Y59985
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
