Helium

First marketed in 1934

Details

Stereochemistry	ACHIRAL
Molecular Formula	He
Molecular Weight	4.0026
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[He]

InChI

InChIKey=SWQJXJOGLNCZEY-UHFFFAOYSA-N

InChI=1S/He

HIDE SMILES / InChI

Molecular Formula	He
Molecular Weight	4.0026
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1480052834488.pdf | https://www.ncbi.nlm.nih.gov/pubmed/27736154

Helium is a chemical element with symbol He and atomic number 2. It is inert, non-toxic odorless gas. In medicine, helium is used to help the flow of oxygen in diseases such as bronchitis, or to assist breathing if part of lungs fails to expand. The mixture of helium and oxygen is known as heliox.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Chronic obstructive pulmonary disease 174 Sources: http://www.mhra.gov.uk/home/groups/spcpil/documents/spcpil/con1480052834488.pdf	Inactive ingredient	Approved 8429	Unknown Approved Use Medical Helium is a very light gas and flows through openings in the lungs with obstructions much more easily than other medical gases. Medical Helium will always be given to you with Medical Oxygen. Medical Helium is used to assist you to breathe if part of the lung fails to expand.
Bronchiolitis 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23509160	Inactive ingredient	Phase III 656	Unknown Approved Use Unknown
Asthma 241 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23664767	Inactive ingredient	Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trial.	2013 Apr	23509160
Evaluation of lung function and deposition of aerosolized bronchodilators carried by heliox associated with positive expiratory pressure in stable asthmatics: a randomized clinical trial.	2013 Aug	23664767
A Multicenter Randomized Trial Assessing the Efficacy of Helium/Oxygen in Severe Exacerbations of Chronic Obstructive Pulmonary Disease.	2017 Apr 1	27736154

Patents

Sample Use Guides

In Vivo Use Guide

Medical helium is administered by inhalation.

Route of Administration: Respiratory

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:15:26 GMT 2023` Edited by `admin` on `Fri Dec 15 16:15:26 GMT 2023`
Record UNII	206GF3GB41
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Helium

Systematic Name

English

INS NO.939

Code

English

E-939

Code

English

INS-939

Code

English

HELIUM [FCC]

Common Name

English

HELIUM [VANDF]

Common Name

English

HELIUM [USP MONOGRAPH]

Common Name

English

HELIUM [MART.]

Common Name

English

HELIUM [EP MONOGRAPH]

Common Name

English

HELIUM [MI]

Common Name

English

Helium [WHO-DD]

Common Name

English

HELIUM-4

Common Name

English

HELIUM [HSDB]

Common Name

English

HELIUM [GREEN BOOK]

Common Name

English

Classification Tree Code System Code

JECFA EVALUATION

INS-939