BRASOFENSINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H20Cl2N2O
Molecular Weight	327.249
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO\N=C\[C@H]1[C@H]2CC[C@@H](C[C@@H]1C3=CC=C(Cl)C(Cl)=C3)N2C

InChI

InChIKey=NRLIFEGHTNUYFL-QJDHNRDASA-N

InChI=1S/C16H20Cl2N2O/c1-20-11-4-6-16(20)13(9-19-21-2)12(8-11)10-3-5-14(17)15(18)7-10/h3,5,7,9,11-13,16H,4,6,8H2,1-2H3/b19-9+/t11-,12+,13+,16+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C16H20Cl2N2O
Molecular Weight	327.249
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11847938 | https://adisinsight.springer.com/drugs/800004288

NeuroSearch was developing brasofensine (or NS 2214), an oral dopamine reuptake inhibitor for the treatment of Parkinson's disease. Brasofensine successfully passed phase II clinical trial in patients with Parkinson's disease, The drug was safe and well tolerated. However, NeuroSearch discontinued the development of the drug because of the cis-anti isomerization of the 2α-methyloxime group of brasofensine in favor of NS 2230.

Originator

Approval Year

PubMed

Title	Date	PubMed
Brasofensine treatment for Parkinson's disease in combination with levodopa/carbidopa.	2002 Feb	11847938
Drugs in development for Parkinson's disease.	2004 Jul	15298067
Disposition and metabolism of [14C]brasofensine in rats, monkeys, and humans.	2008 Jan	17908924

Patents

Sample Use Guides

In Vivo Use Guide

a single oral dose of brasofensine 0.5, 1, 2, or 4 mg, which was coadministered with the patient's usual dose of levodopa/carbidopav

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:20:46 GMT 2023` Edited by `admin` on `Sat Dec 16 17:20:46 GMT 2023`
Record UNII	1YP2S94RVH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BRASOFENSINE

Official Name

English

3.BETA.-(3,4-DICHLOROPHENYL)-1.ALPHA.H,5.ALPHA.H-TROPANE-2.ALPHA.-CARBOXALDEHYDE (E)-(O-METHYLOXIME)

Common Name

English

brasofensine [INN]

Common Name

English

Brasofensine [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149