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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H20F3N3O4
Molecular Weight 411.375
Optical Activity ( - )
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CADROFLOXACIN

SMILES

C[C@H]1CN(CCN1)C2=C(OC(F)F)C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(O)=O

InChI

InChIKey=QBDBUKJBJJWZMG-VIFPVBQESA-N
InChI=1S/C19H20F3N3O4/c1-9-7-24(5-4-23-9)15-13(20)6-11-14(17(15)29-19(21)22)25(10-2-3-10)8-12(16(11)26)18(27)28/h6,8-10,19,23H,2-5,7H2,1H3,(H,27,28)/t9-/m0/s1

HIDE SMILES / InChI

Molecular Formula C19H20F3N3O4
Molecular Weight 411.375
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description
Curator's Comment: Description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/8723467

Cadrofloxacin hydrochloride was studied for the treatment of bacterial infections. The compound was originally developed by UBE and Daiichi Sankyo. However, this study was discontinued. The compound currently was developed by Hengrui. Cadrofloxacin showed potent bactericidal activity against S. aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: Staphylococcus aureus growth
Target ID: Streptococcus pneumoniae growth
Target ID: Haemophilus influenzae growth
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
[Determination of antimycobacterial activities of fluoroquinolones against clinical isolates of Mycobacterium tuberculosis: comparative determination with egg-based Ogawa and agar-based Middlebrook 7H10 media].
1996 Aug
[In vitro anti-MAC activities of new quinolones in focus (1)].
1996 Sep
Patents

Sample Use Guides

400 mg cadrofloxacin hydrochloride once a day for 7 d by intravenous drip infusion
Route of Administration: Intravenous
In Vitro Use Guide
Cadrofloxacin (CS-940) was active against methicillin-resistant S. aureus with MIC90 of 16 ug/ml.
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:18:25 GMT 2023
Edited
by admin
on Sat Dec 16 17:18:25 GMT 2023
Record UNII
1YOQ7J9ACY
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CADROFLOXACIN
INN  
INN  
Official Name English
(-)-1-CYCLOPROPYL-8-(DIFLUOROMETHOXY)-6-FLUORO-1,4-DIHYDRO-7-((S)-3-METHYL-1-PIPERAZINYL)-4-OXO-3-QUINOLINECARBOXYLIC ACID
Systematic Name English
cadrofloxacin [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C795
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
Code System Code Type Description
CAS
153808-85-6
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
SMS_ID
300000036891
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
PUBCHEM
189912
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
ChEMBL
CHEMBL2110804
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
INN
7845
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
FDA UNII
1YOQ7J9ACY
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
EPA CompTox
DTXSID201026510
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
MESH
C487845
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
NCI_THESAURUS
C76229
Created by admin on Sat Dec 16 17:18:26 GMT 2023 , Edited by admin on Sat Dec 16 17:18:26 GMT 2023
PRIMARY
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