BD-1047

CN(C)CCN(C)CCC1=CC=C(Cl)C(Cl)=C1

InChIKey=MGVRNMUKTZOQOW-UHFFFAOYSA-N

InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Sigma opioid receptor 63 Target ID: CHEMBL287 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1310114	Antagonist 2778		1.26 nM [Ki]

PubMed

Title	Date	PubMed
Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism.	1995 Jul 14	8566098
Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.	2003 May 1	12736327
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.	2005 Apr	15723099
Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.	2008 Jan	18173806
The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.	2009 Dec	20054487
Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.	2010 Jun 10	20354174

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 10:56:10 UTC 2023` Edited by `admin` on `Sat Dec 16 10:56:10 UTC 2023`
Record UNII	1S3X75QGDO
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

BD-1047

Common Name

English

1,2-ETHANEDIAMINE, N1-(2-(3,4-DICHLOROPHENYL)ETHYL)-N1,N2,N2-TRIMETHYL-

Systematic Name

English

1,2-ETHANEDIAMINE, N-(2-(3,4-DICHLOROPHENYL)ETHYL)-N,N',N'-TRIMETHYL-

Systematic Name

English

Code System Code Type Description

EPA CompTox

DTXSID70160640