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Details

Stereochemistry ACHIRAL
Molecular Formula C13H20Cl2N2
Molecular Weight 275.217
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BD-1047

SMILES

CN(C)CCN(C)CCC1=CC=C(Cl)C(Cl)=C1

InChI

InChIKey=MGVRNMUKTZOQOW-UHFFFAOYSA-N
InChI=1S/C13H20Cl2N2/c1-16(2)8-9-17(3)7-6-11-4-5-12(14)13(15)10-11/h4-5,10H,6-9H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C13H20Cl2N2
Molecular Weight 275.217
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
1.26 nM [Ki]
PubMed

PubMed

TitleDatePubMed
Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism.
1995 Jul 14
Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity.
1999 Apr 16
Involvement of the sigma1 receptor in the cocaine-induced conditioned place preference.
2000 Sep 11
Sigma 1 receptor-related neuroactive steroids modulate cocaine-induced reward.
2003 May 1
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol.
2004 Jun 11
The dextromethorphan analog dimemorfan attenuates kainate-induced seizures via sigma1 receptor activation: comparison with the effects of dextromethorphan.
2005 Apr
Cocaine and sigma-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model.
2005 Dec
Sigma1 receptor ligands and related neuroactive steroids interfere with the cocaine-induced state of memory.
2006 Jul
Sigma 1 receptor-mediated increase in hippocampal extracellular dopamine contributes to the mechanism of the anticonvulsant action of neuropeptide Y.
2007 Dec
Dimemorfan protects rats against ischemic stroke through activation of sigma-1 receptor-mediated mechanisms by decreasing glutamate accumulation.
2008 Jan
Anti-inflammatory effects of dimemorfan on inflammatory cells and LPS-induced endotoxin shock in mice.
2008 Jul
The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.
2009 Dec
Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.
2010 Jun 10
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 10:56:10 GMT 2023
Edited
by admin
on Sat Dec 16 10:56:10 GMT 2023
Record UNII
1S3X75QGDO
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BD-1047
Common Name English
1,2-ETHANEDIAMINE, N1-(2-(3,4-DICHLOROPHENYL)ETHYL)-N1,N2,N2-TRIMETHYL-
Systematic Name English
1,2-ETHANEDIAMINE, N-(2-(3,4-DICHLOROPHENYL)ETHYL)-N,N',N'-TRIMETHYL-
Systematic Name English
Code System Code Type Description
EPA CompTox
DTXSID70160640
Created by admin on Sat Dec 16 10:56:10 GMT 2023 , Edited by admin on Sat Dec 16 10:56:10 GMT 2023
PRIMARY
FDA UNII
1S3X75QGDO
Created by admin on Sat Dec 16 10:56:10 GMT 2023 , Edited by admin on Sat Dec 16 10:56:10 GMT 2023
PRIMARY
PUBCHEM
188914
Created by admin on Sat Dec 16 10:56:10 GMT 2023 , Edited by admin on Sat Dec 16 10:56:10 GMT 2023
PRIMARY
CAS
138356-20-4
Created by admin on Sat Dec 16 10:56:10 GMT 2023 , Edited by admin on Sat Dec 16 10:56:10 GMT 2023
PRIMARY
WIKIPEDIA
BD-1047
Created by admin on Sat Dec 16 10:56:10 GMT 2023 , Edited by admin on Sat Dec 16 10:56:10 GMT 2023
PRIMARY
Related Record Type Details
ACTIVE MOIETY