NANTERINONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H15N3O
Molecular Weight	253.2991
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CN(C(C)=N1)C2=CC(C)=C3NC(=O)C=CC3=C2

InChI

InChIKey=NMNXBEXPAHSXOK-UHFFFAOYSA-N

InChI=1S/C15H15N3O/c1-9-6-13(18-8-10(2)16-11(18)3)7-12-4-5-14(19)17-15(9)12/h4-8H,1-3H3,(H,17,19)

HIDE SMILES / InChI

Molecular Formula	C15H15N3O
Molecular Weight	253.2991
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://adisinsight.springer.com/drugs/800000177 | https://www.ncbi.nlm.nih.gov/pubmed/8842505

Nanterinone [UK 61260], a phosphodiesterase III inhibitor, was undergoing II evaluation with Pfizer in the US for the treatment of heart failure. Nanterinone is a positive inotropic and balanced-type vasodilating drug, only partially based on phosphodiesterase III inhibition. Preliminary data from controlled studies suggest satisfactory long-term efficacy and safety.

Originator

Approval Year

PubMed

Title	Date	PubMed
2(1H)-quinolinones with cardiac stimulant activity. 3. Synthesis and biological properties of 6-imidazol-1-yl derivatives.	1989 Jul	2544726
Characterization of the arteritis induced by infusion of rats with UK-61,260, an inodilator, for 24 h. A comparison with the arteritis induced by fenoldopam mesylate.	1995	8572928

Sample Use Guides

In Vivo Use Guide

An oral dose of 2 mg nanterinone was studied in 14 patients with heart failure. All patients received placebo and nanterinone on 2 consecutive days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:37:50 GMT 2023` Edited by `admin` on `Fri Dec 15 15:37:50 GMT 2023`
Record UNII	1S169L7KAV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NANTERINONE

Official Name

English

6-(2,4-DIMETHYLIMIDAZOL-1-YL)-8-METHYL-2-QUINOLONE

Systematic Name

English

nanterinone [INN]

Common Name

English

NANTERINONE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C744