Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H12O3S |
Molecular Weight | 284.33 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CC1=CC2=C(C=C1)C(=O)C3=C(CS2)C=CC=C3
InChI
InChIKey=KLIVRBFRQSOGQI-UHFFFAOYSA-N
InChI=1S/C16H12O3S/c17-15(18)8-10-5-6-13-14(7-10)20-9-11-3-1-2-4-12(11)16(13)19/h1-7H,8-9H2,(H,17,18)
Molecular Formula | C16H12O3S |
Molecular Weight | 284.33 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Tiopinac is a tricyclic compound with anti-inflammatory and analgesic effects in animals, ability to inhibit prostaglandin synthesis, and modest antiplatelet aggregation properties in humans. The manufacturer withdrew tiopinac from investigation because of toxicity at higher doses. Tiopinac did not have significant cardiovascular or CNS activity. Lack of anorexia and emesis in dogs with up to 30 mg/kg p.o. and mild oral activity in producing gastric erosion in acute and subacute studies in rats suggests that tiopinac may have relatively little gastrointestinal irritating activity.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
The anti-inflammatory and analgesic profile of 6,11-dihydrodibenzo-[b.e.]-thiepin-11-one-3-acetic acid (tiopinac). | 1980 Jun |
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Tiopinac in rheumatoid arthritis: a three-phase dose-ranging, efficacy, and aspirin-withdrawal protocol. | 1980 May |
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Tiopinac absorption, distribution, excretion, and pharmacokinetics in man and animals. | 1980 Nov-Dec |
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11-[3-(Dimethyl-amino)prop-yl]-6,11-dihydro-dibenzo[b,e]thiepin-11-ol. | 2009 Dec 16 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6989545
25 or 50 mg/ day for 4 wk
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:23:46 GMT 2023
by
admin
on
Fri Dec 15 15:23:46 GMT 2023
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Record UNII |
1QX5LNW7CG
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C257
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1QX5LNW7CG
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61220-69-7
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C024834
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C152642
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100000077234
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Related Record | Type | Details | ||
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