Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C18H33NO4 |
| Molecular Weight | 327.4589 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCC\C(=C/CCCCCCCC(O)=O)[N+]([O-])=O
InChI
InChIKey=WRADPCFZZWXOTI-BMRADRMJSA-N
InChI=1S/C18H33NO4/c1-2-3-4-5-8-11-14-17(19(22)23)15-12-9-6-7-10-13-16-18(20)21/h15H,2-14,16H2,1H3,(H,20,21)/b17-15+
| Molecular Formula | C18H33NO4 |
| Molecular Weight | 327.4589 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:04:20 GMT 2025
by
admin
on
Mon Mar 31 21:04:20 GMT 2025
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| Record UNII |
1N19AGY57Y
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Code | English | ||
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Common Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
701019
Created by
admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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88127-53-1
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NON-SPECIFIC STEREOCHEMISTRY | |||
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DB15026
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PRIMARY | |||
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DTXSID401347887
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PRIMARY | |||
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1N19AGY57Y
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admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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PRIMARY | |||
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875685-46-4
Created by
admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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PRIMARY | |||
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300000020411
Created by
admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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PRIMARY | |||
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CXA-10
Created by
admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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PRIMARY | 10-Nitrooleate: Item NO. 10008043, CAS NO. 875685-46-4Description: Synonyms - (1)10-Nitrooleic Acid, (2)10-nitro-9-trans-Octadecenoic AcidNitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2Item No. 10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPAR.GAMMA. and can also decompose or be metabolized to release nitric oxide. 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (Item No. 10008042) (OA-NO2, used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo. Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 +/- 52 nM and 302 +/- 369 nM, respectively. OA-NO2 activates PPAR.GAMMA. approximately 7-fold at a concentration of 1 uM. and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 uM. | ||
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24836820
Created by
admin on Mon Mar 31 21:04:20 GMT 2025 , Edited by admin on Mon Mar 31 21:04:20 GMT 2025
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PRIMARY |
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ACTIVE MOIETY |
Originator: Complexa; Class: Nitro compound, Small molecule, Unsaturated fatty acid; Mechanism of Action: Inflammation mediator modulator, Signal transduction pathway modulator, Transcription factor modulator; Orphan Drug Status: No; On Fast track: No; New Molecular Entity: Yes; Highest Development Phase: Phase I for Acute kidney injury, Renal failure; Most Recent Events: 16 May 2016 Chemical information added, 12 Nov 2015 Complexa plans phase II trials for Focal segmental glomerulosclerosis (FSGS), Pulmonary arterial hypertension (PAH) and Sickle cell disease in USA, 12 Nov 2015 Complexa completes four phase I trials (NCT02127190, NCT02248051, NCT02460146, NCT02313064) in Acute kidney injury in USA
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ACTIVE MOIETY |
potential
therapeutic effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles.
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