Details
Stereochemistry | RACEMIC |
Molecular Formula | C17H25NO2 |
Molecular Weight | 275.3859 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(=O)O[C@]1(C[C@H](C)N(C)C[C@H]1C)C2=CC=CC=C2
InChI
InChIKey=UVITTYOJFDLOGI-KEYYUXOJSA-N
InChI=1S/C17H25NO2/c1-5-16(19)20-17(15-9-7-6-8-10-15)11-14(3)18(4)12-13(17)2/h6-10,13-14H,5,11-12H2,1-4H3/t13-,14+,17+/m1/s1
Molecular Formula | C17H25NO2 |
Molecular Weight | 275.3859 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 3 / 3 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Trimeperidine (promedol) is the earliest and mostly studied opioid analgesic. Trimeperidine stimulates opioid receptors in the central nervous system. Compared with morphine, it has a weaker and shorter analgesic effect, less affects the respiratory, vomiting and vagal centers, does not cause smooth muscle spasm (except for the myometrium), and has a moderate antispasmodic and hypnotic effect. It is used to treat severe pain syndrome, acute left ventricular failure, pulmonary edema, cardiogenic shock, preparation for surgery, childbirth, high fever, post-transfusion complications, poisoning with atropine, barbiturates, barium, gasoline, boric acid, strong acids, carbon monoxide, turpentine, formalin, formalin. It has several side effects. Administration of this substance is associated with the development of life-threatening conditions accompanied by the suppression of respiration center. Analgesic trimeperidine (promedol) was included into the health care kits by various Ministries of the Russian Federation at different times.
Approval Year
PubMed
Title | Date | PubMed |
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[Characteristics of anesthesia in children operated on for extrahepatic portal hypertension]. | 2001 Jan-Feb |
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[Combined use of narcotic analgesics and non-steroidal anti-inflammatory drugs in the analgesia of injured patients before hospitalization]. | 2002 Jul-Aug |
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[Study of analgesic efficacy of propacetamol in the postoperative period using a double blind placebo controlled method]. | 2002 Jul-Aug |
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[Use of epidural analgesia for the arresting of pronounced lumbar pains]. | 2003 Jul-Aug |
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[Effect of premedication on the formation of postoperative pain syndrome]. | 2003 Jul-Aug |
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[Clinical aspects of using patient-controlled analgesia with nonsteroidal anti-inflammatory agents in postoperative period]. | 2003 Sep-Oct |
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[Postoperative analgesia with nonsteroid anti-inflammatory drugs in children]. | 2004 Jan-Feb |
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[Method of continuous intravenous postoperative analgesia with promedol in newborn children]. | 2004 Jan-Feb |
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[A new method of anaesthesia in laparoscopic cholecystectomy]. | 2005 |
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[Comparative analysis of antiarrhythmic and proarrhythmogenic effects of drugs for neuroleptanalgesia, ataralgesia, and antidepranalgesia in experimental acute myocardial infarction]. | 2006 Jul-Aug |
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[Clinical aspects of analgesia with intravenous paracetamol in the early postoperative period]. | 2006 Nov-Dec |
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[Intraoperative use of Xefocam at laparoscopic cholecystectomy]. | 2006 Nov-Dec |
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[Efficacy and safety of lornoxicam in an early postoperative period]. | 2007 |
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[Factors predisposing to acute urine retention in patients with prostatic adenoma]. | 2007 Mar-Apr |
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[Current approaches to the analgesia of spontaneous child birth]. | 2007 Nov-Dec |
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Half a gram--a thousand lives. | 2008 Jun 24 |
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[Analgesic and opioid-sparing effects of intravenous paracetamol in the early period after aortocoronary bypass surgery]. | 2008 Sep-Oct |
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[Multimodal approach to postoperative analgesia in patients with neuropathic pain]. | 2008 Sep-Oct |
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[Comparison of analgesics using two devices for the patient-controlled analgesia]. | 2009 Jul-Aug |
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[Impact of preemptive analgesia on postoperative pain syndrome in laparoscopic surgery]. | 2009 Nov-Dec |
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[Anesthetic maintenance during circular face lifting]. | 2010 Mar-Apr |
Patents
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:36:42 GMT 2023
by
admin
on
Fri Dec 15 16:36:42 GMT 2023
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Record UNII |
1M2IB31DTS
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Record Status |
Validated (UNII)
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Record Version |
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NCI_THESAURUS |
C67413
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DEA NO. |
9646
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20055107
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200-583-3
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64-39-1
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NON-SPECIFIC STEREOCHEMISTRY | |||
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TRIMEPERIDINE
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SUB11303MIG
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C76848
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1M2IB31DTS
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713
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m9169
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CHEMBL2107685
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100000076922
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DTXSID501018271
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29606-10-8
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
APPROXIMATE PURE ANHYDROUS DRUG CONTENT (IN PERCENT)
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Related Record | Type | Details | ||
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ACTIVE MOIETY |