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Details

Stereochemistry RACEMIC
Molecular Formula C15H10BrClN2O2
Molecular Weight 365.609
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 3-HYDROXYPHENAZEPAM

SMILES

OC1N=C(C2=CC=CC=C2Cl)C3=CC(Br)=CC=C3NC1=O

InChI

InChIKey=KRJKJUWAZOWXNV-UHFFFAOYSA-N
InChI=1S/C15H10BrClN2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)

HIDE SMILES / InChI
Molecular Formula C15H10BrClN2O2
Molecular Weight 365.609
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Positive Allosteric Modulator
179
PubMed

PubMed

TitleDatePubMed
Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam.
2016 Nov
Substance Class Chemical
Created
by admin
on Sat Dec 16 10:19:24 UTC 2023
Edited
by admin
on Sat Dec 16 10:19:24 UTC 2023
Record UNII
1KJ8MP77JK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
3-HYDROXYPHENAZEPAM
Common Name English
7-BROMO-5-(2-CHLOROPHENYL)-3-HYDROXY-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE
Systematic Name English
2H-1,4-BENZODIAZEPIN-2-ONE, 7-BROMO-5-(2-CHLOROPHENYL)-1,3-DIHYDRO-3-HYDROXY-
Systematic Name English
3-HYDROXYFENAZEPAM
Common Name English
Classification Tree Code System Code
WIKIPEDIA Designer-drugs-3-Hydroxyphenazepam
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
Code System Code Type Description
SMS_ID
100000175980
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY
FDA UNII
1KJ8MP77JK
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY
CAS
70030-11-4
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY
PUBCHEM
125820
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY
WEB RESOURCE
3-HYDROXYPHENAZEPAM
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY Novel benzodiazepine, 3-Hydroxyphenazepam
WIKIPEDIA
3-HYDROXYPHENAZEPAM
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY 3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties. It is an active metabolite of phenazepam, as well as the active metabolite of the benzodiazepine prodrug cinazepam. Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards. Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor. It has been sold online as a designer drug.
EPA CompTox
DTXSID10990281
Created by admin on Sat Dec 16 10:19:24 UTC 2023 , Edited by admin on Sat Dec 16 10:19:24 UTC 2023
PRIMARY
Related Record Type Details
Structure of PHENAZEPAM
PARENT -> METABOLITE ACTIVE
in rat and mouse
URINE
Related Record Type Details
Structure of 3-HYDROXYPHENAZEPAM
ACTIVE MOIETY
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