Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H10BrClN2O2 |
| Molecular Weight | 365.609 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1N=C(C2=CC=CC=C2Cl)C3=CC(Br)=CC=C3NC1=O
InChI
InChIKey=KRJKJUWAZOWXNV-UHFFFAOYSA-N
InChI=1S/C15H10BrClN2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
| Molecular Formula | C15H10BrClN2O2 |
| Molecular Weight | 365.609 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays. | 2017-04 |
|
| Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam. | 2016-11 |
|
| Analysis of phenazepam and 3-hydroxyphenazepam in post-mortem fluids and tissues. | 2015-10 |
|
| [Kinetics of hydrolysis of 1,4-benzodiazepine derivative by carboxylesterases in mice organism]. | 2014-12-17 |
|
| [Peculiarities of hypnotic effect and pharmacokinetics of hemisuccinate 3-hydroxyphenazepam (levana)]. | 2014 |
|
| [Comparative kinetics of 3-hydroxyphenazepam and its metabolism during transdermal and intravenous administration]. | 2003-08-20 |
|
| Biokinetics of transdermal 3-hydroxyphenazepam. | 2002-09 |
|
| Modulation of GABAA receptor-mediated currents by phenazepam and its metabolites. | 2001-07 |
|
| [Pharmacokinetics of fenazepam and its metabolite 3-oxyfenazepam in animals of different species and in man]. | 1985-01-01 |
|
| [Spectral changes in the liver microsomal cytochrome P-450 of rats during interaction with phenazepam and its 3-hydroxy metabolite]. | 1984-08 |
|
| [Characteristics of fenazepam excretion in rats and mice]. | 1983-05-01 |
|
| [Simulation of kinetics of phenazepam and its metabolite 3-hydroxyphenazepam in cat blood]. | 1982-10 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 23:10:32 GMT 2025
by
admin
on
Mon Mar 31 23:10:32 GMT 2025
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| Record UNII |
1KJ8MP77JK
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| Record Status |
Validated (UNII)
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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WIKIPEDIA |
Designer-drugs-3-Hydroxyphenazepam
Created by
admin on Mon Mar 31 23:10:32 GMT 2025 , Edited by admin on Mon Mar 31 23:10:32 GMT 2025
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| Code System | Code | Type | Description | ||
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100000175980
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1KJ8MP77JK
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70030-11-4
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125820
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3-HYDROXYPHENAZEPAM
Created by
admin on Mon Mar 31 23:10:32 GMT 2025 , Edited by admin on Mon Mar 31 23:10:32 GMT 2025
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PRIMARY | Novel benzodiazepine, 3-Hydroxyphenazepam | ||
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3-HYDROXYPHENAZEPAM
Created by
admin on Mon Mar 31 23:10:32 GMT 2025 , Edited by admin on Mon Mar 31 23:10:32 GMT 2025
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PRIMARY | 3-Hydroxyphenazepam is a benzodiazepine with hypnotic, sedative, anxiolytic, and anticonvulsant properties. It is an active metabolite of phenazepam, as well as the active metabolite of the benzodiazepine prodrug cinazepam. Relative to phenazepam, 3-hydroxyphenazepam has diminished myorelaxant properties, but is about equivalent in most other regards. Like other benzodiazepines, 3-hydroxyphenazepam behaves as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor. It has been sold online as a designer drug. | ||
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DTXSID10990281
Created by
admin on Mon Mar 31 23:10:32 GMT 2025 , Edited by admin on Mon Mar 31 23:10:32 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
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PARENT -> METABOLITE ACTIVE |
in rat and mouse
URINE
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
