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Details

Stereochemistry ACHIRAL
Molecular Formula C21H21NO4
Molecular Weight 351.3957
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ZINDOXIFENE

SMILES

CCN1C2=C(C=C(OC(C)=O)C=C2)C(C)=C1C3=CC=C(OC(C)=O)C=C3

InChI

InChIKey=KSZGVNZSUJHOJA-UHFFFAOYSA-N
InChI=1S/C21H21NO4/c1-5-22-20-11-10-18(26-15(4)24)12-19(20)13(2)21(22)16-6-8-17(9-7-16)25-14(3)23/h6-12H,5H2,1-4H3

HIDE SMILES / InChI

Molecular Formula C21H21NO4
Molecular Weight 351.3957
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Zindoxifene (D 16726 or 5-acetoxy-2-(4-acetoxyphenyl)-1-ethyl-3-methylindole), is an antiestrogenic phenylindole with a high affinity for the estrogen receptor. Zindoxifene exerts inhibiting activity against tumors of prostatic and mammary origins both in vitro and in vivo. It was in phase I/II study for the treatment of advanced breast cancer. Zindoxifene development has been discontinued.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

PubMed

Sample Use Guides

In Vivo Use Guide
phase I/II study for the treatment of advanced breast cancer: oral zindoxifene doses ranged from 10 to 100 mg daily
Route of Administration: Oral
Substance Class Chemical
Record UNII
1IRS95M8DN
Record Status Validated (UNII)
Record Version