FLUSOXOLOL

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C22H30FNO4
Molecular Weight	391.4763
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)NC[C@H](O)COC1=CC=C(OCCOCCC2=CC=C(F)C=C2)C=C1

InChI

InChIKey=CYCXZGUVPDRYLG-FQEVSTJZSA-N

InChI=1S/C22H30FNO4/c1-17(2)24-15-20(25)16-28-22-9-7-21(8-10-22)27-14-13-26-12-11-18-3-5-19(23)6-4-18/h3-10,17,20,24-25H,11-16H2,1-2H3/t20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H30FNO4
Molecular Weight	391.4763
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1363945 | https://www.ncbi.nlm.nih.gov/pubmed/2868899 | https://adisinsight.springer.com/drugs/800000411

Flusoxolol (Ro 31-1411), a pharmacologically active optical isomer of Ro 31-1118 is a cardioselective beta-adrenoceptor antagonist. Flusoxolol was studied for the treatment of patients with ischemic heart disorders; however, the further development of the drug has been discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
Ro 31-1118, a new cardioselective beta-adrenoceptor antagonist. Pharmacokinetics and effects on heart rate and blood pressure in mild hypertensives.	1985	2868899
[The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium].	1992 Sep-Oct	1363945

Sample Use Guides

In Vivo Use Guide

It was given to 6 healthy volunteers in a single dose, 40 mg, and then in multiple doses, 40 mg daily for 8 days.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:48:13 UTC 2023` Edited by `admin` on `Fri Dec 15 15:48:13 UTC 2023`
Record UNII	1GPL60IRCI
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUSOXOLOL

Official Name

English

RO 31-1411

Code

English

(S)-1-(P-(2-((P-FLUOROPHENETHYL)OXY)ETHOXY)PHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL

Common Name

English

flusoxolol [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29576